Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.010 Biomarker disease BEFREE Our findings suggest that the heat shock proteins CPN10, CPN60, and CPN70 might have potential as biomarkers for BD and CPN60 blood level might distinguish patients with abnormal HPA axis activity from those with normal HPA axis activity. 29979378 2018
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.010 Biomarker disease BEFREE Immunohistochemical analyses showed significantly elevated levels of HSPE1 in tumor cells compared with non-cancerous bladder epithelial cells, suggesting that HSPE1 could be a useful tumor tissue marker for the specific detection of bladder cancer. 30112103 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 Biomarker disease BEFREE Immunohistochemical analyses showed significantly elevated levels of HSPE1 in tumor cells compared with non-cancerous bladder epithelial cells, suggesting that HSPE1 could be a useful tumor tissue marker for the specific detection of bladder cancer. 30112103 2018
CUI: C0005940
Disease: Bone Diseases
Bone Diseases 		0.010 Biomarker group BEFREE Our findings suggest that Mt cpn10 may be a valuable pharmacological target for the clinical therapy of vertebral tuberculosis and possibly other bone diseases. 9334363 1997
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives. 19913561 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 Biomarker disease BEFREE In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. 31564980 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 Biomarker group LHGDN Detection and identification of heat shock protein 10 as a biomarker in colorectal cancer by protein profiling. 16502466 2006
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.010 Biomarker disease BEFREE In this study the prevalence of antibodies against the heat shock protein 10 (HSP10) of Chamydophila pneumoniae (CP) (as assessed by ELISA) in patients with coronary heart disease (CHD) and seropositive or seronegative to CP, as assessed by microimmunofluorescence (MIF), was investigated. 15893396 2005
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 Biomarker disease BEFREE These results suggest that an autoantibody against HSP 10 is also a new diagnostic marker for both AIP and FT1DM. 19520060 2009
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.010 Biomarker group LHGDN A strategy for high-resolution protein identification in surface-enhanced laser desorption/ionization mass spectrometry: calgranulin A and chaperonin 10 as protein markers for endometrial carcinoma. 15816004 2005
CUI: C0019270
Disease: Hernia
Hernia 		0.010 Biomarker phenotype BEFREE Western blotting showed that urinary ANXA3 and HSPE1 protein levels were higher in bladder cancer samples than in hernia samples, and enzyme-linked immunosorbent assays confirmed a higher urinary concentration of HSPE1 in bladder cancer than in hernia, hematuria and urinary tract infection. 30112103 2018
CUI: C0023343
Disease: Leprosy
Leprosy 		0.010 Biomarker disease BEFREE To address the issue of epitope recognition in mycobacterial diseases, we have analysed 16 peptides (15-mer peptides) spanning the entire ML and M. tuberculosis GroES protein in leprosy (n = 19) and tuberculosis (n = 9) patients and healthy endemic controls (n = 8). 15056384 2004
CUI: C0023351
Disease: Tuberculoid leprosy
Tuberculoid leprosy 		0.010 Biomarker disease BEFREE Peripheral blood mononuclear cells (PBMC) from treated tuberculoid leprosy or lepromatous leprosy patients and from healthy household or hospital staff contacts of the patients were cultured with 20 16-mer peptides covering the entire sequences of both M. leprae and M. tuberculosis GroES. 9746595 1998
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 Biomarker disease BEFREE Hence, Cpn10 might be useful for the treatment of skin and kidney manifestations of SLE. 21987536 2012
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.010 Biomarker disease BEFREE Cpn10 also suppressed lupus nephritis as evident from serum creatinine levels, albuminuria and the scores of disease activity and chronicity. 21987536 2012
CUI: C0026916
Disease: Mycobacterium avium-intracellulare Infection
Mycobacterium avium-intracellulare Infection 		0.010 Biomarker disease BEFREE Recombinant GroES in combination with CpG oligodeoxynucleotides protects mice against Mycobacterium avium infection. 12466405 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Furthermore, a literature review shows that Heat shock protein 10 (Hsp10), single-stranded DNA-binding protein (SSBP1), and peptidyl-prolyl cis-trans isomerase A (PPIA), which were identified as being increased in the tumor samples in this study, may be closely related to protein folding and translation. 23589362 2013
CUI: C0027697
Disease: Nephritis
Nephritis 		0.010 Biomarker disease BEFREE In summary, recombinant Cpn10 selectively prevents cutaneous lupus and suppresses nephritis in MRL-(Fas)lpr mice without affecting the underlying systemic autoimmune process. 21987536 2012
CUI: C0036690
Disease: Septicemia
Septicemia 		0.010 Biomarker disease BEFREE miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model. 28662100 2017
CUI: C0041330
Disease: Tuberculosis, Spinal
Tuberculosis, Spinal 		0.010 Biomarker disease BEFREE Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease. 9334363 1997
CUI: C0162565
Disease: Acute intermittent porphyria
Acute intermittent porphyria 		0.010 Biomarker disease BEFREE These results suggest that an autoantibody against HSP 10 is also a new diagnostic marker for both AIP and FT1DM. 19520060 2009
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 Biomarker disease BEFREE miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model. 28662100 2017
CUI: C0376670
Disease: Pancreatitis, Alcoholic
Pancreatitis, Alcoholic 		0.010 Biomarker disease BEFREE We found that autoantibody against HSP 10 was also produced with high frequency in sera from patients with AIP (92%) and FT1DM (81%), but not in chronic alcoholic pancreatitis (8%) or healthy volunteers (1.4%). 19520060 2009
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.010 Biomarker disease BEFREE Immunohistochemical analyses showed significantly elevated levels of HSPE1 in tumor cells compared with non-cancerous bladder epithelial cells, suggesting that HSPE1 could be a useful tumor tissue marker for the specific detection of bladder cancer. 30112103 2018
CUI: C0745287
Disease: infertility tubal factor
infertility tubal factor 		0.010 Biomarker disease BEFREE Associations between Hsp10 seropositivity and TFI were greater in the EB(+) subgroup while associations among the EB(-) subgroup were diminished. 10603402 2000