|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
|
28196617 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Positron emission tomography and post-mortem studies of the number of somatodendritic 5-hydroxytryptamine(1A) (5-HT(1A)) autoreceptors in raphé nuclei have found both increases and decreases in depression.
|
23809646 |
2014 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Disturbances in the 5-HT1A⁻FGFR1 heteroreceptor complexes in the raphe-hippocampal 5-HT system were found in a genetic rat model of depression (Flinders sensitive line (FSL) rats).
|
29865267 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression.
|
20025927 |
2010 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment as a dependent variable.
|
21449006 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression.
|
28920103 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The predictors of delayed remission included unemployment (P = .004), severe medical comorbidity (P < .0001), severe baseline depression (P < .0001), more than 4 dysthymic symptoms (P = .005), more than 9 posttraumatic stress symptoms (P = .005), and serotonin receptor 1A (P = .006) and cytochrome P450 2D6 (P = .002 for C/T and P = .0004 for T/T) genetic variants.
|
29178685 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After controlling for sociodemographic and disease-related factors, alexithymia and HTR1A-G polymorphism, both separately (20-22%) and jointly (14-16%), significantly and independently predicted the development of IFN-induced depression.
|
26609890 |
2015 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The diagnosis of current depression, which was associated with IFN-α-related depression (P<.001), demonstrated a statistically significant association with the CC genotype of the 5-HTR1A gene (odds ratio=5.57, 95% confidence interval=1.61-19.24, P=.007).
|
24462335 |
2015 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders.
|
18639564 |
2008 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consequently, VN2222 is a new compound with a dual effect on the serotonergic system, as 5-HT uptake blocker and 5-HT1A receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity.
|
12020683 |
2002 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Behavioral and molecular biological studies have demonstrated that the differences of 5-HT1A receptor regulation was connected with depression and the responses to antidepressants.
|
31541883 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism in the promoter region of the 5-HT(1A) receptor gene is associated with depression and suicidal behavior.
|
17012696 |
2006 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression
|
31120232 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Specifically, we investigated two serotonin-related genes including three substitutions connected to human emotional states such as despondency and depression: the tryptophan hydroxylase (TPH) gene (A779C and A218C in the intron) and the serotonin1A (5-HT1A) receptor gene (Pro 16Leu in the cording region).
|
14998306 |
2004 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT1A receptor plays a critical role in the pathophysiology of anxiety and depression as well as in the mode of action of anxiolytic and antidepressant drugs.
|
14666415 |
2003 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest an impact of allelic variation in 5-HT(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression.
|
17408646 |
2007 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our study, the HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.
|
21512427 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While multiple lines of evidence implicate the 5-HT1A receptor in the pathophysiology of anxiety and depression as well as in the mechanism of action of anxiolytics/antidepressants, its relevance to the therapeutic effectiveness of these drugs has been a matter of considerable debate (for review see Griebel, 1995; Hensler, 2003; Hjorth et al., 2000; Lesch et al., 2003).
|
15683551 |
2004 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correction: Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.
|
31586041 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, modulation of glucocorticoid receptor (GR) and serotonin receptor 1A (5-HTR1A) were implicated in mechanism(s) leading to depression.
|
15885359 |
2005 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Depression diagnosis was not associated with MAO-A genotype or 5-HT(1A) receptor availability in these regions.
|
18971477 |
2008 |