|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regions-of-interest (ROI) assessed were the mesiotemporal cortex (hippocampus-amygdala) and midbrain raphe, where previous postmortem studies suggested 5HT1A receptor binding is abnormal in depression.
|
10578452 |
1999 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression.
|
11704418 |
2001 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serotonin1A (5-HT1A) receptor has been under intense investigation, mostly due to its putative role in both the etiology and therapeutic treatments of depression and anxiety-related behaviors.
|
11742136 |
2001 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consequently, VN2222 is a new compound with a dual effect on the serotonergic system, as 5-HT uptake blocker and 5-HT1A receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity.
|
12020683 |
2002 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The measurement of 5-HT1A receptors in drug-naïve schizophrenic patients using the in vivo PET methodology revealed an increase of cortical 5-HT1A receptor binding potential in schizophrenia. beta-CIT as a ligand for measurement of 5-HT transporter densities (5-HTT) revealed lower rates in depression compared to age- and sex-matching healthy controls, a measurement that has also been obtained for bulimia.
|
12478878 |
2002 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT1A receptor plays a critical role in the pathophysiology of anxiety and depression as well as in the mode of action of anxiolytic and antidepressant drugs.
|
14666415 |
2003 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Specifically, we investigated two serotonin-related genes including three substitutions connected to human emotional states such as despondency and depression: the tryptophan hydroxylase (TPH) gene (A779C and A218C in the intron) and the serotonin1A (5-HT1A) receptor gene (Pro 16Leu in the cording region).
|
14998306 |
2004 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While multiple lines of evidence implicate the 5-HT1A receptor in the pathophysiology of anxiety and depression as well as in the mechanism of action of anxiolytics/antidepressants, its relevance to the therapeutic effectiveness of these drugs has been a matter of considerable debate (for review see Griebel, 1995; Hensler, 2003; Hjorth et al., 2000; Lesch et al., 2003).
|
15683551 |
2004 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors review evidence that altered transcription of the 5-HT1A receptor can affect the serotonin system and limbic and cortical areas, leading to predisposition to depression.
|
15534042 |
2004 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several studies have demonstrated the involvement of 5-HT1A receptors in the pathogenesis of depression and in the antidepressant response to SSRIs.
|
15458611 |
2004 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, modulation of glucocorticoid receptor (GR) and serotonin receptor 1A (5-HTR1A) were implicated in mechanism(s) leading to depression.
|
15885359 |
2005 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism in the promoter region of the 5-HT(1A) receptor gene is associated with depression and suicidal behavior.
|
17012696 |
2006 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AN have higher 5-HT(1A) than controls and AE suggesting a model of depression characterized by an over expression of autoinhibitory somatodendritic 5-HT(1A) receptors, perhaps due to the higher expressing G allele, that may result in reduced terminal field 5-HT release.
|
16154547 |
2006 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Alterations in 5-HT1A receptor levels are implicated in mood disorders, and a functional C(-1019)G 5-HT1A promoter polymorphism has been associated with depression, suicide, and panic disorder.
|
16467535 |
2006 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest an impact of allelic variation in 5-HT(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression.
|
17408646 |
2007 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
|
17401528 |
2007 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While the study has several limitations, the results are consistent with a growing body of literature that suggests that the pharmacogenetics of depression (an inherently complex disorder) may turn out to be multifactorial, and may include the HTR1A gene in concert with other serotonin-related genes.
|
17570737 |
2007 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders.
|
18639564 |
2008 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Depression diagnosis was not associated with MAO-A genotype or 5-HT(1A) receptor availability in these regions.
|
18971477 |
2008 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present study adds to the clarification of the role of 5-HT1A variation in treatment response in major depression by providing preliminary support for poor treatment response mediated by the 5-HT1A-1019C allele repressing 5-HT1A activity specifically in the melancholic subtype of depression.
|
18387740 |
2008 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.
|
19829169 |
2009 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression.
|
20025927 |
2010 |