|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Depression diagnosis was not associated with MAO-A genotype or 5-HT(1A) receptor availability in these regions.
|
18971477 |
2008 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression
|
31120232 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism in the promoter region of the 5-HT(1A) receptor gene is associated with depression and suicidal behavior.
|
17012696 |
2006 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After controlling for sociodemographic and disease-related factors, alexithymia and HTR1A-G polymorphism, both separately (20-22%) and jointly (14-16%), significantly and independently predicted the development of IFN-induced depression.
|
26609890 |
2015 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Alterations in 5-HT1A receptor levels are implicated in mood disorders, and a functional C(-1019)G 5-HT1A promoter polymorphism has been associated with depression, suicide, and panic disorder.
|
16467535 |
2006 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AN have higher 5-HT(1A) than controls and AE suggesting a model of depression characterized by an over expression of autoinhibitory somatodendritic 5-HT(1A) receptors, perhaps due to the higher expressing G allele, that may result in reduced terminal field 5-HT release.
|
16154547 |
2006 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
As previous studies have implicated dysfunction of the hippocampal 5-HT1A receptor (5-HT1AR) in depressive disorders, we also evaluated the effect of KSS on 5-HT1AR expression and the protein kinase A- (PKA-) cAMP response element-binding- (CREB-) brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus in this model.
|
31781286 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenotypes and response to antidepressants is proposed.
|
22826341 |
2012 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Behavioral depression was assessed by sucrose preference test (SPT) and the expression of Serotonin 1A (5-HT1A) receptor in the hippocampal.
|
31467884 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Behavioral and molecular biological studies have demonstrated that the differences of 5-HT1A receptor regulation was connected with depression and the responses to antidepressants.
|
31541883 |
2019 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consequently, VN2222 is a new compound with a dual effect on the serotonergic system, as 5-HT uptake blocker and 5-HT1A receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity.
|
12020683 |
2002 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correction: Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.
|
31586041 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Disturbances in the 5-HT1A⁻FGFR1 heteroreceptor complexes in the raphe-hippocampal 5-HT system were found in a genetic rat model of depression (Flinders sensitive line (FSL) rats).
|
29865267 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment as a dependent variable.
|
21449006 |
2011 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.
|
30664620 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders.
|
18639564 |
2008 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Human studies implicate a polymorphism in the promoter of the serotonin-1A (5-HT(1A)) receptor gene in increased susceptibility to depression and decreased treatment response.
|
20152112 |
2010 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our study, the HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.
|
21512427 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
|
24337875 |
2014 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression.
|
28920103 |
2017 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes.
|
29636529 |
2018 |