HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease CTD_human
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD). 31228794 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)]. 25990886 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie rs6313" genes_norm="3356">102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD. 24801750 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie 102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD. 24801750 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression. 15469201 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis. 25270656 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis. 25270656 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. 24962835 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. 24962835 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. 19937159 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Insomnia symptom of MDD was not resolved in patients with the A/A genotype of HTR2A-rs6311 when treated with SSRI. 31111219 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD. 21741447 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635 2003
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE No significant association between the 5-HTR2A gene SNP rs6311 and the risk of MDD was observed by four genetic models in the current meta-analysis (P = 0·12 for A versus G; P = 0·11 for AA versus GG; P = 0·06 for AA+AG versus GG; P = 0·24 for AG+GG versus AA). 23317793 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008). 25108775 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease PSYGENET Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008). 25108775 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome. 21838737 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553 2000
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population. 14730199 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression. 11311507 2001
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE Pharmacological studies have yielded valuable insights into the role of the serotonin 2A (5-HT2A) receptor in major depressive disorder (MDD) and antidepressant drugs (ADs) response. 26764241 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease BEFREE Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD. 23547754 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191 2000