|
Acute infectious disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We observed that NO and NOS II mRNA were induced at higher levels in acutely infected macrophages than in persistently infected macrophages, while the kinetics of NOS II protein expression were similar in both types of infected cultures, except that its disappearance was delayed during acute infection.
|
31177351 |
2019 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Amputated ovarian tissues completely regenerate as a result of the proliferation of residual GSCs, but nanos2 mutant ovaries fail to regenerate after amputation due to a lack of GSCs.
|
30759383 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to examine the topographical and cellular distribution of inducible nitric oxide synthase (iNOS or NOS II) within different stages of atherosclerosis and its colocalization with ceroid deposits and nitrotyrosine.
|
10690346 |
1999 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to examine the topographical and cellular distribution of inducible nitric oxide synthase (iNOS or NOS II) within different stages of atherosclerosis and its colocalization with ceroid deposits and nitrotyrosine.
|
10690346 |
1999 |
|
Benign Prostatic Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inducible NOS (iNOS or NOS-2) is not detected in normal prostate, while it is expressed in the prostate of all benign prostatic hyperplasia (BPH) patients, even in the absence of prostatitis or systemic signs of an inflammatory condition.
|
10547579 |
1999 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the (CCTTT)n NOS2 microsatellite may influence the risk of developing lung cancer, especially in non-smokers, possibly by affecting intracellular nitric oxide levels.
|
24408018 |
2014 |
|
Cerebral Palsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the risk for cerebral palsy (CP) increases when an expansion of the - 2.5 kb (CCTTT)n microsatellite in the NOS2A gene and a single nucleotide polymorphism (SNP) in -C511T of the IL- IL-1β gene promoter occur in patients after perinatal hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Chronic heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Polymerase chain reaction results indicated that NOS II gene expression is increased in patients with chronic heart failure.
|
9768718 |
1998 |
|
Common Cold
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased NOS 2 expression was also observed in nasal epithelial scrapings during symptomatic colds.
|
11174188 |
2001 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Polymerase chain reaction results indicated that NOS II gene expression is increased in patients with chronic heart failure.
|
9768718 |
1998 |
|
Cryptorchidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression levels of miR-34c and Nanos2 with cryptorchidism in humans and mice were examined.
|
30322389 |
2018 |
|
Disorder of the optic nerve
|
0.010 |
AlteredExpression
|
group |
BEFREE |
As demonstrated by several independent methods, glaucomatous optic neuropathy was not associated with a significant change in the expression of NOS-2 in the retina, ONH, or optic nerve.
|
15790897 |
2005 |
|
Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Combined allergic airway sensitization and O<sub>3</sub> exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways.
|
29733456 |
2018 |
|
Eosinophilic disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Combined allergic airway sensitization and O<sub>3</sub> exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways.
|
29733456 |
2018 |
|
Glaucoma, Primary Open Angle
|
0.010 |
Biomarker
|
disease |
BEFREE |
Similarly, there was no difference in NOS-2 immunoreactivity in the optic nerve or ONH between POAG and nonglaucomatous eyes.
|
15790897 |
2005 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The haplotype (CCTTT)<sub>14</sub>/TT, formed by the expansion of the - 2.5 kb (CCTTT)<sub>n</sub> microsatellite in the NOS2A gene promoter and the -511 C➝ T SNP of the IL-1β gene promoter, might be a useful marker to identify patients who are at high risk for developing CP after hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Intraocular pressure disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Retinal and ONH NOS-2 mRNA levels did not correlate with either IOP level or severity of optic nerve injury.
|
15790897 |
2005 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that the levels of NO in patients suffering from HCC metastasis were lower compared to those without metastasis (P<0.05) and NOS-2 expression was correlated with tumor diameter (P<0.05) and metastasis (P<0.05).
|
23007408 |
2012 |
|
Male infertility
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
The miR-34c/Nanos2 pathway provides new insight into the mechanism of male infertility caused by cryptorchidism.
|
30322389 |
2018 |
|
Male infertility
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Male sterility
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the (CCTTT)n NOS2 microsatellite may influence the risk of developing lung cancer, especially in non-smokers, possibly by affecting intracellular nitric oxide levels.
|
24408018 |
2014 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Therefore the NOS II gene appears to be a promising suicide gene therapy of human cancer.
|
11045428 |
2001 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Many studies have demonstrated the function of nitric oxide (NO) or nitric oxide synthase-2 (NOS-2) in cancer as pro-neoplastic or anti-neoplastic effectors, but the role of NO and NOS-2 in hepatocellular carcinoma (HCC) remains unclear.
|
23007408 |
2012 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumors formed in the tongues of SCID mice xenografted with OSC-4, NOS-2, and OSC-7 immunohistochemically revealed strong, moderate, and weak expression of laminin-5 gamma2 chains, respectively, and laminin-5 gamma2 chains were secreted in the conditioned medium of the cancer cells in parallel with the in vivo results.
|
16707450 |
2006 |