|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, use of the NOS II gene in cancer therapy is problematic because of the double-edged nature of NO action.
|
15939886 |
2005 |
|
Meconium Aspiration Syndrome
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our data thus indicate that intrapulmonary meconium up-regulates lung COX-2 and NOS-2 gene expression, suggesting an important role for prostaglandins and nitric oxide in the meconium aspiration-induced pulmonary inflammation and hemodynamic changes.
|
12621123 |
2003 |
|
Medullary carcinoma of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We orthotopically transplanted rMTC 6-23 cells into the inbred strain of Wag/Rij rats and constructed a plasmid carrying the NOS II gene under the control of the cytomegalovirus (CMV) promoter.
|
11045428 |
2001 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We found that the levels of NO in patients suffering from HCC metastasis were lower compared to those without metastasis (P<0.05) and NOS-2 expression was correlated with tumor diameter (P<0.05) and metastasis (P<0.05).
|
23007408 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Both simvastatin and fluvastatin enhanced nitric oxide ((.)NO) levels which were inhibited by mevalonate.Statin-induced (.)NO and tumor cell cytotoxicity were inhibited by 1400W, a more specific inhibitor of inducible nitric oxide synthase (iNOS or NOS II).
|
17671209 |
2007 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We found that the levels of NO in patients suffering from HCC metastasis were lower compared to those without metastasis (P<0.05) and NOS-2 expression was correlated with tumor diameter (P<0.05) and metastasis (P<0.05).
|
23007408 |
2012 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Inducible NOS II is expressed by microglia and macrophages invading during tumour growth.
|
10769672 |
2000 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We analyzed the associations of the NOS2 (CCTTT)n promoter polymorphism to lung cancer risk and tumor histology in smokers and non-smokers.
|
24408018 |
2014 |
|
Ocular Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, an NOS-2 inhibitor, aminoguanidine, administered orally in the drinking water, was tested for its effect on optic nerve injury in rats with ocular hypertension.
|
15790897 |
2005 |
|
Optic Neuropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As demonstrated by several independent methods, glaucomatous optic neuropathy was not associated with a significant change in the expression of NOS-2 in the retina, ONH, or optic nerve.
|
15790897 |
2005 |
|
Perinatal anoxic-ischemic brain injury
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the risk for cerebral palsy (CP) increases when an expansion of the - 2.5 kb (CCTTT)n microsatellite in the NOS2A gene and a single nucleotide polymorphism (SNP) in -C511T of the IL- IL-1β gene promoter occur in patients after perinatal hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumors formed in the tongues of SCID mice xenografted with OSC-4, NOS-2, and OSC-7 immunohistochemically revealed strong, moderate, and weak expression of laminin-5 gamma2 chains, respectively, and laminin-5 gamma2 chains were secreted in the conditioned medium of the cancer cells in parallel with the in vivo results.
|
16707450 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Therefore the NOS II gene appears to be a promising suicide gene therapy of human cancer.
|
11045428 |
2001 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, use of the NOS II gene in cancer therapy is problematic because of the double-edged nature of NO action.
|
15939886 |
2005 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Many studies have demonstrated the function of nitric oxide (NO) or nitric oxide synthase-2 (NOS-2) in cancer as pro-neoplastic or anti-neoplastic effectors, but the role of NO and NOS-2 in hepatocellular carcinoma (HCC) remains unclear.
|
23007408 |
2012 |
|
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the (CCTTT)n NOS2 microsatellite may influence the risk of developing lung cancer, especially in non-smokers, possibly by affecting intracellular nitric oxide levels.
|
24408018 |
2014 |
|
Primary sclerosing cholangitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results show that: (1) tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, synergically stimulate NO production in cultured cholangiocytes through an increase in NOS2 gene and protein expression; (2) micromolar concentrations of NO inhibit forskolin-stimulated cAMP production by adenylyl cyclase (AC), cyclic adenosine monophosphate (cAMP)-dependent fluid secretion, and cAMP-dependent Cl(-) and HCO(3)(-) transport mediated by cystic fibrosis transmembrane conductance regulator (CFTR) and anion exchanger isoform 2, respectively; (3) cholestatic effects of NO and of proinflammatory cytokines are prevented by NOS-2 inhibitors and by agents (manganese(III)-tetrakis(4-benzoic acid)porphyrin [MnTBAP], urate, trolox) able to block the formation of reactive nitrogen oxide species (RNOS); (4) NOS2 expression is increased significantly in the biliary epithelium of patients with primary sclerosing cholangitis (PSC).
|
12612912 |
2003 |
|
Progressive cGVHD
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NOS-2 activity was markedly diminished at the time of stoma closure, but remained elevated in infants who died from progressive disease.
|
9044137 |
1997 |
|
Progressive Neoplastic Disease
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
NOS-2 activity was markedly diminished at the time of stoma closure, but remained elevated in infants who died from progressive disease.
|
9044137 |
1997 |
|
prostatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inducible NOS (iNOS or NOS-2) is not detected in normal prostate, while it is expressed in the prostate of all benign prostatic hyperplasia (BPH) patients, even in the absence of prostatitis or systemic signs of an inflammatory condition.
|
10547579 |
1999 |
|
Rhinovirus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased epithelial expression of NOS 2 mRNA occurs as part of the host response to HRV infection in vitro and in vivo.
|
11174188 |
2001 |
|
Subfertility, Male
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Systemic Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining also showed that NOS-2 proteins were detected in SSc fibroblasts but not in normal fibroblasts.
|
14632763 |
2003 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The depth of interstitial and endovascular intrauterine trophoblast invasion and the immunohistochemical expression of vascular endothelial growth factor (VEGF), fetal liver kinase 1 (Flk1), interferon (IFN)-γ, migration inhibitory factor (MIF), and inducible nitric oxide synthase (iNOS; also known as nitric oxide synthase (NOS) 2) were evaluated.
|
27737730 |
2017 |