|
Male infertility
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
The miR-34c/Nanos2 pathway provides new insight into the mechanism of male infertility caused by cryptorchidism.
|
30322389 |
2018 |
|
Male infertility
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Subfertility, Male
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Male sterility
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male.
|
22190708 |
2012 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We analyzed the associations of the NOS2 (CCTTT)n promoter polymorphism to lung cancer risk and tumor histology in smokers and non-smokers.
|
24408018 |
2014 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Many studies have demonstrated the function of nitric oxide (NO) or nitric oxide synthase-2 (NOS-2) in cancer as pro-neoplastic or anti-neoplastic effectors, but the role of NO and NOS-2 in hepatocellular carcinoma (HCC) remains unclear.
|
23007408 |
2012 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We found that the levels of NO in patients suffering from HCC metastasis were lower compared to those without metastasis (P<0.05) and NOS-2 expression was correlated with tumor diameter (P<0.05) and metastasis (P<0.05).
|
23007408 |
2012 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Many studies have demonstrated the function of nitric oxide (NO) or nitric oxide synthase-2 (NOS-2) in cancer as pro-neoplastic or anti-neoplastic effectors, but the role of NO and NOS-2 in hepatocellular carcinoma (HCC) remains unclear.
|
23007408 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Both simvastatin and fluvastatin enhanced nitric oxide ((.)NO) levels which were inhibited by mevalonate.Statin-induced (.)NO and tumor cell cytotoxicity were inhibited by 1400W, a more specific inhibitor of inducible nitric oxide synthase (iNOS or NOS II).
|
17671209 |
2007 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumors formed in the tongues of SCID mice xenografted with OSC-4, NOS-2, and OSC-7 immunohistochemically revealed strong, moderate, and weak expression of laminin-5 gamma2 chains, respectively, and laminin-5 gamma2 chains were secreted in the conditioned medium of the cancer cells in parallel with the in vivo results.
|
16707450 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumors formed in the tongues of SCID mice xenografted with OSC-4, NOS-2, and OSC-7 immunohistochemically revealed strong, moderate, and weak expression of laminin-5 gamma2 chains, respectively, and laminin-5 gamma2 chains were secreted in the conditioned medium of the cancer cells in parallel with the in vivo results.
|
16707450 |
2006 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, use of the NOS II gene in cancer therapy is problematic because of the double-edged nature of NO action.
|
15939886 |
2005 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, use of the NOS II gene in cancer therapy is problematic because of the double-edged nature of NO action.
|
15939886 |
2005 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Therefore the NOS II gene appears to be a promising suicide gene therapy of human cancer.
|
11045428 |
2001 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Therefore the NOS II gene appears to be a promising suicide gene therapy of human cancer.
|
11045428 |
2001 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Inducible NOS II is expressed by microglia and macrophages invading during tumour growth.
|
10769672 |
2000 |
|
Cerebral Palsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the risk for cerebral palsy (CP) increases when an expansion of the - 2.5 kb (CCTTT)n microsatellite in the NOS2A gene and a single nucleotide polymorphism (SNP) in -C511T of the IL- IL-1β gene promoter occur in patients after perinatal hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Acute infectious disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We observed that NO and NOS II mRNA were induced at higher levels in acutely infected macrophages than in persistently infected macrophages, while the kinetics of NOS II protein expression were similar in both types of infected cultures, except that its disappearance was delayed during acute infection.
|
31177351 |
2019 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Amputated ovarian tissues completely regenerate as a result of the proliferation of residual GSCs, but nanos2 mutant ovaries fail to regenerate after amputation due to a lack of GSCs.
|
30759383 |
2019 |
|
Perinatal anoxic-ischemic brain injury
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the risk for cerebral palsy (CP) increases when an expansion of the - 2.5 kb (CCTTT)n microsatellite in the NOS2A gene and a single nucleotide polymorphism (SNP) in -C511T of the IL- IL-1β gene promoter occur in patients after perinatal hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The haplotype (CCTTT)<sub>14</sub>/TT, formed by the expansion of the - 2.5 kb (CCTTT)<sub>n</sub> microsatellite in the NOS2A gene promoter and the -511 C➝ T SNP of the IL-1β gene promoter, might be a useful marker to identify patients who are at high risk for developing CP after hypoxic-ischemic encephalopathy.
|
29931509 |
2019 |
|
Cryptorchidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression levels of miR-34c and Nanos2 with cryptorchidism in humans and mice were examined.
|
30322389 |
2018 |
|
Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Combined allergic airway sensitization and O<sub>3</sub> exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways.
|
29733456 |
2018 |
|
Eosinophilic disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Combined allergic airway sensitization and O<sub>3</sub> exposure heightened eosinophilia and nos2 mRNA (iNOS) activation in the lung tissue and S-nitrosylation related de-oligomerisation of SP-D in the airways.
|
29733456 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The depth of interstitial and endovascular intrauterine trophoblast invasion and the immunohistochemical expression of vascular endothelial growth factor (VEGF), fetal liver kinase 1 (Flk1), interferon (IFN)-γ, migration inhibitory factor (MIF), and inducible nitric oxide synthase (iNOS; also known as nitric oxide synthase (NOS) 2) were evaluated.
|
27737730 |
2017 |