|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660-2664) have indicated that a survival factor gene is located in band 11q23, and that the highly informative microsatellite polymorphism at the APOC3 locus would be a suitable tool to perform more extensive LOH studies.
|
10360669 |
1999 |
|
Presenile dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study shows the relevance of polymorphisms in APOB (odds ratio (OR), 1.17; 95% confidence interval (95% CI), 0.74-1.85), APOC3 (OR, 1.33; 95% CI, 0.82-2.17) and APOE (OR, 1.75; 95% CI, 1.09-2.80), as genetic risk markers for hypercholesterolemia; polymorphisms in ACE (OR, 1.68; 95% CI, 0.32-8.77) and AGT (OR, 1.74; 95% CI, 0.97-3.14) for hypertension; and in APOE*3/*4 (OR, 2.06; 95% CI, 1.70-2.51) and APOE*4/*4 (OR, 3.08; 95% CI, 1.85-5.12) as unambiguous markers of dementia.
|
29081697 |
2017 |
|
Premature coronary artery atherosclerosis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These findings indicate that the polymorphism in the region between the apolipoprotein A-I and apolipoprotein C-III genes may be a useful marker for the risk of premature coronary artery disease and familial hypoalphalipoproteinemia.
|
3081805 |
1986 |
|
Premature coronary artery atherosclerosis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Finally, restriction mapping analysis of DNA from a patient with combined APOA1-APOC3 deficiency and premature coronary artery disease indicated that this patient has a structurally normal APOA4 gene.
|
3095836 |
1986 |
|
Pregnancy associated hypertension
|
0.010 |
GeneticVariation
|
phenotype |
LHGDN |
The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension.
|
17318300 |
2007 |
|
Pregnancy associated hypertension
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension.
|
17318300 |
2007 |
|
Prader-Willi Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of apoC-III hyposialylation in PWS.
|
20825553 |
2010 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Phosphatidylinositol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic architecture of human plasma lipidome and its link to cardiovascular disease.
|
31551469 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The most prominent finding among PD adults was an increased appearance of Tf C2 allele and significant mean hypoglycosylation of ApoCIII, besides a C2/e4 positive correlation in PD seniors.
|
22118861 |
2012 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
An antisense oligonucleotide to apolipoprotein-C3, volanesorsen has been shown to decrease TGs by 70-80% and possibly to reduce rates of pancreatitis admissions.
|
29842811 |
2018 |
|
Overnutrition
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We concluded that APOC3, whose dysregulation is liable for hypertriglyceridemia, is not a predisposing factor for linking overnutrition to NAFLD in obesity.
|
28115523 |
2017 |
|
Ostium secundum atrial septal defect
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three different polymorphisms located in the prothrombin, F2 (20210G/A), and apolipoprotein-C3 (-641A/C and -455T/A) genes were significantly associated with ICVD and PFO.
|
22784820 |
2013 |
|
obsolete Combined hyperlipidemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PCSK9 significantly conferred prediction of both hypercholesterolemia and combined hyperlipidemia at a level of 235 ng/ml; apoC3 levels for hypertriglyceridemia, hypercholesterolemia and combined hyperlipidemia were 80.0, 71.5, and 86.4 μg/ml, respectively; and sdLDL-C for hypertriglyceridemia, hypercholesterolemia, combined hyperlipidemia and hypo high density lipoprotein (HDL) cholesterolemia 3.5, 2.5, 4.5, and 2.5 mg/dl, respectively (all p<0.001 for area under the receiver-operating characteristic curve).
|
27713142 |
2017 |
|
Obesity, Visceral
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content.
|
21829161 |
2012 |
|
Obesity
|
0.080 |
Biomarker
|
disease |
BEFREE |
APOC3 -482TT genotype is associated with high apoC-III concentrations only in the presence of abdominal obesity or insulin resistance, but not in current smokers who remain lean or insulin-sensitive.
|
21185820 |
2011 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The odds ratios for MI for the APOC3*222 haplotype were 1.72 (95% CI: 1.16, 2.54) and 1.84 (1.31, 2.59) in subjects in the lowest quintiles of abdominal obesity and fasting hyperglycemia, respectively, and were 0.75 (0.54, 1.05) and 1.16 (0.85, 1.59) in subjects in the highest quintiles, respectively (P for interaction <0.05).
|
18541587 |
2008 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis with adjustment for age, sex, and the prevalence of smoking revealed that the -30Gright curved arrow A polymorphism of GCK, the -240Aright curved arrow T polymorphism of ACE, and the -482Cright curved arrow T polymorphism of APOC3 were significantly (P < 0.01) associated with the prevalence of obesity, and the -1989Tright curved arrow G polymorphism of ESR1 was almost significantly associated.
|
17016614 |
2006 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the APOC3 (-455T>C) polymorphism and obesity, impaired glucose tolerance, hyperuricemia, hypercholesterolemia, or high levels of low-density lipoprotein cholesterol (LDL) (P > 0.05).
|
25320541 |
2014 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate such association between the APOC3 -482C>T polymorphism and cardiometabolic risk factors in the turkish adult risk factor (TARF) study cohort, stratifying by gender and obesity.
|
22004016 |
2011 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In multivariate regression models, the c56C > G SNP, plasma apoCIII, plasma nonesterified fatty acids, hepatic APOA5 transcripts, sex and a weak association with obesity status explained 61% of the variance in apoAV plasma levels.
|
18537870 |
2008 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Results Variant genotypes of polymorphisms -863 C > A and -1031 T > C of the TNFA gene, 455 T > C of the APOC3 gene and the wild type of +276 G > T of the ADIPOQ gene were associated with obesity with odds ratios (OR, 95% confidence interval [CI]) of 2.5 (1.5-4.4), 2.5 (1.5-4.2), 2.0 (1.1-3.6) and 2.5 (1.4-5.0), respectively.
|
31216264 |
2019 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The APOC3 rs2070666 A allele is a risk factor for NAFLD independent of obesity, dyslipidemia, and PNPLA3 rs738409, and it might contribute to increased liver fat content in Chinese Han population.
|
27059980 |
2016 |
|
Nuchal bleb, familial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In FCH the X2 minor allele of the AI-CIII-AIV gene cluster was associated with increased fasting plasma TG, apo CIII, apo AI, and NEFA concentrations and decreased postheparin lipolytic activities.
|
8100834 |
1993 |
|
Nuchal bleb, familial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
J. Lipid Res., 1996, 36:136-147) we have studied three restriction enzyme polymorphisms: XmnI, and MspI sites 5' of the apo AI gene and SstI site in the 3' untranslated region of exon 4 of the apo CIII gene in 18 FCH pedigrees, including 18 probands, 178 hyperlipidemic relatives, 210 normolipidemic relatives, and 176 spouses.
|
9062353 |
1997 |