|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the IFNAR1 chain of type 1 interferon receptor in benign cells protects against progression of acute leukemia.
|
28503979 |
2018 |
|
Acute type B viral hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A higher expression of T-bet, PD-1, IFN-r and perforin was observed in acute stage when compared with the recovery stage of AHB.
|
26809262 |
2016 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
To validate this hypothesis, in this work we determined whether the inactivation of type I interferon receptor (Ifnar1) would ameliorate the phenotype of Klf1 KO mice by improving the lethal anemia.
|
29230002 |
2018 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate the method by building two complex gene-SNP networks around Interferon Receptor 12B2 (IL12RB2) and Interleukin 1B (IL1B), two biologic candidates in asthma pathogenesis, using 534,290 genotyped variants and gene expression data on 22,177 genes from total RNA derived from peripheral blood CD4+ lymphocytes from 154 asthmatics.
|
19473523 |
2009 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death.
|
19957332 |
2010 |
|
Bluetongue infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunization of knock-out α/β interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen.
|
21320537 |
2011 |
|
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Formation of human IFN-beta complex with the soluble type I interferon receptor IFNAR-2 leads to enhanced IFN stability, pharmacokinetics, and antitumor activity in xenografted SCID mice.
|
14980076 |
2004 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death.
|
19957332 |
2010 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The overexpression found in ganglion cells suggests that IFN-R could be involved in the pathway of neuroblastoma differentiation.
|
9864419 |
1999 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we test the hypothesis that the type I interferon receptor (IFNAR1) plays a critical role in neural injury after stroke by regulating the resultant pro-inflammatory environment.
|
28647375 |
2017 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The control group exhibited a greater frequency of IFNAR-1 expression (10/17; 58.3%) than the CIN samples (4/28; 14.2%) (P = 0.0018), while, the expression of IFNAR-2 was also greater in the control samples (11/17; 64.7%) than in the patients with lesions (2/28; 7.1%) (P = 0.0018).
|
19381629 |
2009 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
A key immune mechanism underlying the safety of VSVΔG-CHIKV, VSVΔG-H5N1, and VLV in the adult brain was the type I interferon response; all three viruses were lethal in the brains of adult mice lacking the interferon receptor, suggesting that the viruses can infect and replicate and spread in brain cells if not blocked by interferon-stimulated genes within the brain.<b>IMPORTANCE</b> Vesicular stomatitis virus (VSV) shows considerable promise both as a vaccine vector and as an oncolytic virus.
|
28077641 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The overexpression found in ganglion cells suggests that IFN-R could be involved in the pathway of neuroblastoma differentiation.
|
9864419 |
1999 |
|
Coinfection
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Co-infection was associated with lower IFNAR2 mRNA levels, higher levels of serum HCV RNA, and a poor IFN response, regardless of the HCV genotype.
|
11170061 |
2001 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
The frequencies of IFNAR1 and IFNAR2 in lymphocytes and monocytes were significantly increased in CHB and LC patients than in healthy controls.
|
23663046 |
2013 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was no difference on mRNA levels of IFNA, IFNG, INFGR2, IFNAR1 and IFNAR2 between DS and euploid individuals, even though some of these genes are located on chromosome 21.
|
22995210 |
2012 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We quantified IFNAR mRNA expression in paired tumor and non-tumor samples from the surgical specimens of 103 consecutive patients with RCC using a real-time reverse transcription polymerase chain reaction (RT-PCR), and IFNAR2 protein using Western blotting.
|
17697365 |
2007 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We measured serum IFNAR2 mRNA levels and quantified IFNAR mRNA expression in paired tumor and non-tumor tissues from the surgical specimens of 66 consecutive RCC patients by the real-time reverse transcription polymerase chain reaction (RT-PCR).
|
21350947 |
2011 |
|
Dengue Fever
|
0.020 |
Biomarker
|
disease |
BEFREE |
Compared with pups of naive mothers, those born to ZIKV-immune mice lacking type I interferon receptor in myeloid cells (LysMCre<sup>+</sup>Ifnar1<sup>fl/fl</sup>) exhibit heightened disease and viremia upon DENV infection.
|
30439343 |
2018 |
|
Dengue Fever
|
0.020 |
Biomarker
|
disease |
BEFREE |
Influence of antibodies and T cells on dengue disease outcome: insights from interferon receptor-deficient mouse models.
|
26001278 |
2015 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.
|
27369778 |
2016 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]).
|
30084830 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]).
|
30084830 |
2018 |
|
Diabetes, Autoimmune
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
|
27999109 |
2017 |
|
Disseminated Bacillus Calmette-Guerin infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inactivating mutations of the gamma-interferon receptor lead to increased susceptibility to typical mycobacteria and disseminated BCG infection in homozygous children.
|
9597143 |
1998 |