Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225252
Disease: IMMUNODEFICIENCY 45
IMMUNODEFICIENCY 45 		0.700 SusceptibilityMutation disease ORPHANET Human IFNAR2 deficiency: Lessons for antiviral immunity. 26424569 2015
CUI: C4225252
Disease: IMMUNODEFICIENCY 45
IMMUNODEFICIENCY 45 		0.700 Biomarker disease GENOMICS_ENGLAND Human IFNAR2 deficiency: Lessons for antiviral immunity. 26424569 2015
CUI: C4225252
Disease: IMMUNODEFICIENCY 45
IMMUNODEFICIENCY 45 		0.700 CausalMutation disease CLINVAR
CUI: C4225252
Disease: IMMUNODEFICIENCY 45
IMMUNODEFICIENCY 45 		0.700 Biomarker disease CTD_human
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.340 GeneticVariation disease BEFREE Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with HBV infection, and IFNLR1-rs4649203 was associated with HBV recovery. 29080269 2018
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.340 GeneticVariation disease BEFREE This study suggests that IFNAR2-F8S polymorphisms might be involved in the susceptibility to chronic HBV infection. 23745570 2013
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.340 GeneticVariation disease BEFREE Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. 19714778 2009
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.340 AlteredExpression disease BEFREE Co-infection by serologically-silent hepatitis B virus may contribute to poor interferon response in patients with chronic hepatitis C by down-regulation of type-I interferon receptor gene expression in the liver. 11170061 2001
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.340 Biomarker disease CTD_human
CUI: C4225260
Disease: IMMUNODEFICIENCY 44
IMMUNODEFICIENCY 44 		0.300 SusceptibilityMutation disease ORPHANET Human IFNAR2 deficiency: Lessons for antiviral immunity. 26424569 2015
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C1864880
Disease: HEPATITIS B VIRUS, SUSCEPTIBILITY TO
HEPATITIS B VIRUS, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation disease CLINVAR
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE This suppressive effect of TNF-α on HCV was due to its role in supporting interferon signaling, as the suppression of its expression led to the loss of IFNAR2 and impaired interferon signaling and the induction of interferon-stimulated genes. 26023919 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE Recent data suggest that vitamin A modulates the expression of type I interferon receptor enhancing the antireplication effect of interferon-α on hepatitis C virus (HCV). 23213086 2013
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 GeneticVariation disease BEFREE This study aims to investigate the association of single-nucleotide polymorphisms (SNPs) of IFNAR2, IL10RB, and IL28RA genes with susceptibility to HCV infection and resolution. 21742059 2011
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease LHGDN Hepatic interferon receptor mRNA expression: clinical relevance and its relationship with effectiveness of interferon plus ribavirin therapy in patients with genotype 1b hepatitis C virus infection. 16518956 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE Hepatic interferon receptor mRNA expression: clinical relevance and its relationship with effectiveness of interferon plus ribavirin therapy in patients with genotype 1b hepatitis C virus infection. 16518956 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE HCV-RNA level: odds ratio 0.23, 95% CI 0.038-0.864; and IFNAR2 in liver: odds ratio 1.116, 95% CI 1.015-1.227). 14996348 2004
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE 9-cis retinoic acid enhances the antiviral effect of interferon on hepatitis C virus replication through increased expression of type I interferon receptor. 12518169 2003
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE Co-infection was associated with lower IFNAR2 mRNA levels, higher levels of serum HCV RNA, and a poor IFN response, regardless of the HCV genotype. 11170061 2001
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.080 AlteredExpression disease BEFREE We investigated whether interferon receptor gene (IFNAR1 and IFNAR2 mRNA) expression in the liver before interferon therapy predicts long-term response to therapy in patients with genotype 2a or 2b HCV infection. 9563926 1998
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.070 Biomarker disease BEFREE This vaccine induced neutralizing antibody responses to both CHIKV and ZIKV in wild-type mice and in interferon receptor-deficient A129 mice, animal models for CHIKV and ZIKV infection. 29807712 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.070 Biomarker disease BEFREE The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR<sup>-/-</sup>) mice is not uniformly lethal particularly in older animals. 29696134 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.070 Biomarker disease BEFREE The transfer of CD4+T cells from ZIKV immune mice protect type I interferon receptor deficient animals from a lethal challenge; showing that the CD4+T cell response is necessary and sufficient for control of ZIKV disease. 30212537 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.070 Biomarker disease BEFREE Here, we investigate the neuropathogenesis of ZIKV infection in type I interferon receptor IFNAR knockout (Ifnar1 <sup>-/-</sup> ) mice, an infection model that exhibits high viral burden within the central nervous system. 29158604 2018