|
IMMUNODEFICIENCY 45
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
IMMUNODEFICIENCY 45
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Hepatitis B
|
0.340 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
HEPATITIS B VIRUS, SUSCEPTIBILITY TO
|
0.100 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Hepatitis C
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
9-cis retinoic acid enhances the antiviral effect of interferon on hepatitis C virus replication through increased expression of type I interferon receptor.
|
12518169 |
2003 |
|
Coinfection
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Co-infection was associated with lower IFNAR2 mRNA levels, higher levels of serum HCV RNA, and a poor IFN response, regardless of the HCV genotype.
|
11170061 |
2001 |
|
Hepatitis C
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
HCV-RNA level: odds ratio 0.23, 95% CI 0.038-0.864; and IFNAR2 in liver: odds ratio 1.116, 95% CI 1.015-1.227).
|
14996348 |
2004 |
|
Multiple Sclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Interferon receptor expression in multiple sclerosis patients.
|
17188754 |
2007 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection.
|
28793350 |
2017 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections.
|
30473701 |
2018 |
|
Superinfection
|
0.010 |
Biomarker
|
group |
BEFREE |
IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections.
|
30473701 |
2018 |
|
Diabetes, Autoimmune
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
|
27999109 |
2017 |
|
Acute type B viral hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A higher expression of T-bet, PD-1, IFN-r and perforin was observed in acute stage when compared with the recovery stage of AHB.
|
26809262 |
2016 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
A key immune mechanism underlying the safety of VSVΔG-CHIKV, VSVΔG-H5N1, and VLV in the adult brain was the type I interferon response; all three viruses were lethal in the brains of adult mice lacking the interferon receptor, suggesting that the viruses can infect and replicate and spread in brain cells if not blocked by interferon-stimulated genes within the brain.<b>IMPORTANCE</b> Vesicular stomatitis virus (VSV) shows considerable promise both as a vaccine vector and as an oncolytic virus.
|
28077641 |
2017 |
|
Henipavirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Altogether, these results reveal IFNAR-KO mice as a new small animal model to study HeV and NiV pathogenesis, prophylaxis, and treatment and suggest the critical role of type I interferon signaling in the control of henipavirus infection.
|
23089589 |
2013 |
|
Virus Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an undefined function distinct from suppression of viral infections.
|
30920934 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.040 |
Biomarker
|
disease |
BEFREE |
Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a significant effect on the primary end point in a previous phase 3 trial.
|
31851795 |
2020 |
|
Hepatitis B, Chronic
|
0.030 |
Biomarker
|
disease |
BEFREE |
Association of IFNAR2 and IL10RB genes in chronic hepatitis B virus infection.
|
23745570 |
2013 |
|
Hepatitis B
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection.
|
19714778 |
2009 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
By multivariate analysis, a high T/N ratio of IFNAR2 predicted a shortened overall survival in all cases (P < 0.05) and a shorter disease-free survival in those without metastasis (M0; 68 cases, P < 0.05).
|
17697365 |
2007 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
By multivariate analysis, a high T/N ratio of IFNAR2 predicted a shortened overall survival in all cases (P < 0.05) and a shorter disease-free survival in those without metastasis (M0; 68 cases, P < 0.05).
|
17697365 |
2007 |
|
Hemorrhagic Fever, Crimean
|
0.020 |
Biomarker
|
disease |
BEFREE |
Cellular and humoral immunogenicity was confirmed in 2 mouse strains, including type I interferon receptor knockout mice, which are susceptible to CCHF disease.
|
26309231 |
2016 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Characterization of Simbu serogroup virus infections in type I interferon receptor knock-out mice.
|
28702933 |
2017 |
|
Hepatitis B
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Co-infection by serologically-silent hepatitis B virus may contribute to poor interferon response in patients with chronic hepatitis C by down-regulation of type-I interferon receptor gene expression in the liver.
|
11170061 |
2001 |
|
Hepatitis C
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Co-infection was associated with lower IFNAR2 mRNA levels, higher levels of serum HCV RNA, and a poor IFN response, regardless of the HCV genotype.
|
11170061 |
2001 |