IFNG, interferon gamma, 3458

N. diseases: 167; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.900 Biomarker disease GENOMICS_ENGLAND Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. 15327519 2004
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.900 Biomarker disease CTD_human
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.600 Biomarker disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.420 Biomarker disease CTD_human Elevated cytokine levels in children with autism spectrum disorder. 16360218 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 Biomarker disease CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443 2012
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.400 Biomarker disease CTD_human IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. 9169506 1997
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.400 Biomarker group CTD_human Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. 19077085 2009
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.400 Biomarker group CTD_human To further define their roles in systemic autoimmunity, IL-4 and IFN-gamma gene knockout mice were studied for susceptibility to the prototypic Th2-mediated mercury-induced autoimmunity. 9647229 1998
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker disease CTD_human Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. 19446661 2009
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.400 Biomarker disease CTD_human Selected biomarkers were able to classify subjects with clear CD/non-CD status, and a subset of the biomarkers (CXCL10, GBP5, IFI27, IFNG, and UBD) showed differential expression in biopsies from subjects with no or low-grade intestinal injury that received a CD diagnosis based on biopsies taken at a later time point. 30097691 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.400 Biomarker disease CTD_human Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation. 24548422 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.400 Biomarker disease CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET Further evidence for the role of interferon-gamma on anxiety- and depressive-like behaviors: involvement of hippocampal neurogenesis and NGF production. 24993299 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
CUI: C0015967
Disease: Fever
Fever 		0.400 Biomarker phenotype CTD_human Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. 18282668 2008
CUI: C0015967
Disease: Fever
Fever 		0.400 Biomarker phenotype CTD_human Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine. 3091246 1986
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease 		0.400 Biomarker disease CTD_human Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. 22077062 2012
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.400 Biomarker group CTD_human Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine. 3091246 1986
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.400 Biomarker disease CTD_human
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.400 Biomarker group CTD_human Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy. 10202824 1999
CUI: C0023281
Disease: Leishmaniasis
Leishmaniasis 		0.400 Biomarker disease CTD_human Elevated levels of interferon-gamma, interleukin-10, and interleukin-6 during active disease in Indian kala azar. 16540374 2006
CUI: C0023281
Disease: Leishmaniasis
Leishmaniasis 		0.400 Biomarker disease CTD_human Circulating nitric oxide and C-reactive protein levels in Indian kala azar patients: correlation with clinical outcome. 17218153 2007
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous 		0.400 Biomarker disease CTD_human Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. 20102417 2010