IFNG, interferon gamma, 3458

N. diseases: 167; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker disease GENOMICS_ENGLAND Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. 15327519 2004
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker disease CTD_human
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.420 Biomarker disease CTD_human Elevated cytokine levels in children with autism spectrum disorder. 16360218 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 Biomarker disease CTD_human Selected biomarkers were able to classify subjects with clear CD/non-CD status, and a subset of the biomarkers (CXCL10, GBP5, IFI27, IFNG, and UBD) showed differential expression in biopsies from subjects with no or low-grade intestinal injury that received a CD diagnosis based on biopsies taken at a later time point. 30097691 2018
CUI: C0009319
Disease: Colitis
Colitis
0.400 Biomarker disease CTD_human Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation. 24548422 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Further evidence for the role of interferon-gamma on anxiety- and depressive-like behaviors: involvement of hippocampal neurogenesis and NGF production. 24993299 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease CTD_human Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators. 23517930 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker disease PSYGENET Paradoxical downregulation of HLA-A expression by IFNγ associated with schizophrenia and noncoding genes. 23083632 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker disease CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443 2012
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.400 Biomarker disease CTD_human Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17. 22077062 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker disease PSYGENET In order to explore the possible relationship between IFNG and schizophrenia, we attempted to analyze the differentially expressed proteins in the brains of interferon-gamma knockout (Ifng-KO) mice. 22623148 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567 2011
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Respiratory Syncytial Virus Infections
0.400 Biomarker group CTD_human Resveratrol-mediated gamma interferon reduction prevents airway inflammation and airway hyperresponsiveness in respiratory syncytial virus-infected immunocompromised mice. 21937650 2011
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.400 Therapeutic disease CTD_human Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus. 20610715 2010
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker disease CTD_human Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. 20102417 2010
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Therapeutic disease CTD_human Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. 20102417 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker disease PSYGENET To characterize the activation status of the immune system in schizophrenia, we examined the pattern of gene expression in peripheral blood cells for three Th1 cytokines (interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2)), and one Th2 cytokine (interleukin-10 (IL-10)). 20132993 2010
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker group CTD_human Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. 19077085 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker disease CTD_human Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. 19446661 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker disease CTD_human Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients. 19446661 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008