|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both ApoE4 carriers and non-ApoE4 carriers with depression had lower Abeta42 and a higher Abeta40/Abeta42 ratio in plasma compared with non-ApoE4 carriers without depression in the homebound elderly.
|
19812466 |
2010 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Within LOD group there is no difference between those with and without ApoE4 accordingly in age of onset of depression, cognitive functions and severity of LOD.
|
22226379 |
2012 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Abnormal FDG-PET was associated with depression as measured by NPI-Q (OR = 2.12; 1.23-3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00-6.69), though marginally significant.
|
27447426 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed additive interactions between APOE ε4 and depression (joint effect HR = 2.21; 95% CI = 1.24-3.91; test for additive interaction, p < 0.001); and between APOE ε4 and apathy (joint effect HR = 1.93; 95% CI = 0.93-3.98; test for additive interaction, p = 0.031).
|
25653291 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.
|
8915560 |
1996 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.
|
25670333 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with apolipoprotein E epsilon 4 were less likely to have psychotic forms of depression.
|
11722155 |
2001 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression.
|
23171142 |
2013 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the APOE*E4 allele predicted future depression in this Swedish population study, even after excluding depressed individuals who later developed dementia, suggesting that the APOE*E4 allele could potentially identify people at high risk for clinically significant depression.
|
25708227 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a Korean community population aged 65+ (n=732), diagnosis of depression (Geriatric Mental State Schedule) and information on vascular status, disability, APOE genotype and cognitive function were obtained.
|
15286060 |
2004 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression and dementia in the elderly have been suggested to share similar risk factors and pathogenetic background, and recently the authors reported that the APOEɛ4 allele is a risk factor for both disorders in the general population.
|
27639288 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is speculation these symptoms result from known genetic risk factors for AD, therefore we investigated the role of apolipoprotein E epsilon4 in the aetiology of depression in AD.
|
15627763 |
2005 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Variables, including depression timeline/onset and its clinical course, apolipoprotein E4 (APOE4) genotype status, sex, dose/duration of antidepressant treatment, and AD biomarkers need to be incorporated in future trials to better elucidate the effect of antidepressants on AD risk.
|
30456746 |
2019 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of APOE ɛ4 allele was higher in participants with dementia than in controls (50% versus 29.4%; p = 0.0002), as was the prevalence of depression (48% versus 32%; p < 0.001).
|
28984595 |
2017 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the association between the APOE epsilon 4 polymorphism and the -491A/T and Th1E47csT/G polymorphisms in a sample of 118 healthy, non-demented controls and 239 consecutively recruited gerontopsychiatric patients diagnosed as: Alzheimer's disease (N = 89), age mild cognitive impairment (N = 32), memory complainers without any cognitive deficit (N = 54) and depression/other psychiatric disorders (N = 64), to test whether the investigated polymorphisms have a high enough selectivity and specificity to distinguish between the different gerontopsychiatric disorders or to differentiate AD genetically from other forms of dementia, respectively.
|
11315514 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, a relation between APOE polymorphism and the age of onset of depression as well as the cognitive outcome of ECT was studied.
|
15791170 |
2005 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations.
|
18641859 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, significant interaction was found between APOE-epsilon4 genotype and SMC on depression.
|
19494432 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the sensitivity and specificity of CSF-tau in clinical practice as a diagnostic marker for AD compared with normal aging and depression, to study the stability of CSF-tau in longitudinal samples, and to determine whether CSF-tau levels are influenced by different covariates such as gender, age, duration or severity of disease, or possession of the APOE-epsilon4 allele.
|
10534256 |
1999 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For example, women generally appear at higher risk than men, as do people with lower levels of education; depression is probably prodromal; head injury is an established risk factor, and may interact with the apoE gene; several occupational exposures appear hazardous, and exposure to aluminum in the water supply confers excess risk.
|
11442298 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No effect of APOE genotype on risk for depression was found.
|
18179845 |
2009 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, little research has investigated whether a history of depression influences the relationship between APOE epsilon4 and CD.
|
19155747 |
2009 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data support the safety of condensed protocols for APOE disclosure for those free of severe anxiety or depression who are actively seeking such information.
|
25499536 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ninety-two community-dwelling elderly individuals participating in a study of white matter hyperintensities (WMHs) in normal aging whose apolipoprotein E (APOE) genotype had been determined completed the Geriatric Depression Scale and received an MRI scan.
|
11384894 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PIF was associated with depression (OR 1.08, 95% CI 1.01 to 1.15; p<0.02) and was inversely associated with APOE ε4 (OR 0.21, 95% CI 0.05 to 0.87; p=0.03), again suggesting a protective effect.
|
20884673 |
2011 |