|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<i>APOE</i> ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, <i>P</i>=0.003; dominant: OR=1.34, 95%CI=1.06-1.68, <i>P</i>=0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82).
|
30834074 |
2019 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.
|
12145452 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression is common in multiple sclerosis (MS) and the role of ApoE alleles is unknown.
|
19244396 |
2009 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depression and APOE act independently to increase the risk for cognitive decline and may provide targets for prevention and early treatment.
|
20374396 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression and dementia in the elderly have been suggested to share similar risk factors and pathogenetic background, and recently the authors reported that the APOEɛ4 allele is a risk factor for both disorders in the general population.
|
27639288 |
2017 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
APO-E may be a risk factor for cerebrovascular disease associated with late-life depression and may affect the clinical characteristics and disease course of depression.
|
10910427 |
2000 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E epsilon4 allele affects the relationship between stress and depression in caregivers of patients with Alzheimer's disease.
|
11563433 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype and hippocampal volume change in geriatric depression.
|
11904138 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ApoE4 allele is associated with late-life depression: a population-based study.
|
17911363 |
2007 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.
|
18058831 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE related hippocampal shape alteration in geriatric depression.
|
19010425 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045).
|
21905099 |
2011 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
ApoE4 is not associated with depression when mild cognitive impairment is considered.
|
22700491 |
2013 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression.
|
23171142 |
2013 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Abnormal FDG-PET was associated with depression as measured by NPI-Q (OR = 2.12; 1.23-3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00-6.69), though marginally significant.
|
27447426 |
2016 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p < .05 and F = 3.2670; p < .05, respectively).
|
27113638 |
2017 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allele frequently of epsilon4 of the apolipoprotein E gene was higher in the ischemic group (11 percent) than the nonischemic group (5 percent) (chi2 = 5.35, P < .05), but there was no significant association between the allele or the genotype frequency of the angiotensin-converting enzyme gene and the incidence of ischemic ST-segment depression.
|
8641725 |
1996 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analyses were adjusted by baseline covariates: age, race, sex, poverty status, marital status, body mass index, smoking status, ApoE4 status, and mCES-D.
|
29254675 |
2018 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As indicated by Cox regression modeling, dementia risk of low-educated individuals was not significantly different between ethnic groups but was related to having an APOE e4 allele (hazard ratio [HR] 1.89), depression (HR 1.67), stroke (HR 1.60), and smoking (HR 1.32).
|
30005921 |
2018 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the apolipoprotein E epsilon4 allele with late-onset depression.
|
11684904 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.
|
8915560 |
1996 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed.
|
18603262 |
2009 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both ApoE4 carriers and non-ApoE4 carriers with depression had lower Abeta42 and a higher Abeta40/Abeta42 ratio in plasma compared with non-ApoE4 carriers without depression in the homebound elderly.
|
19812466 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E.
|
28560728 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Demographic data, the Consortium to Establish a Registry for Alzheimer's Disease 10-word delayed recall, APOE ɛ4 status, Cornell Scale for Depression in Dementia, and comorbid hypertension were used as covariates.
|
28614836 |
2017 |