|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.
|
8915560 |
1996 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allele frequently of epsilon4 of the apolipoprotein E gene was higher in the ischemic group (11 percent) than the nonischemic group (5 percent) (chi2 = 5.35, P < .05), but there was no significant association between the allele or the genotype frequency of the angiotensin-converting enzyme gene and the incidence of ischemic ST-segment depression.
|
8641725 |
1996 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In spite of the association between dementia and APOE polymorphism, as well as dementia and depression, there was no association between APOE polymorphism and depression.
|
9359975 |
1997 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
It was expected that ApoE epsilon 4 allele frequencies would be elevated not only in Alzheimer's disease and dementia in general, but also in first episode, late-life depression accompanied by subtle cognitive impairment (possibly organic depression).
|
9448441 |
1998 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the sensitivity and specificity of CSF-tau in clinical practice as a diagnostic marker for AD compared with normal aging and depression, to study the stability of CSF-tau in longitudinal samples, and to determine whether CSF-tau levels are influenced by different covariates such as gender, age, duration or severity of disease, or possession of the APOE-epsilon4 allele.
|
10534256 |
1999 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n=343) or possible (n=158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria.
|
10322238 |
1999 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the final model (R2 = 0.28), no use of estrogen replacement therapy (P = .006), lower education (P < .001), poorer perceived health status (P = .035), current depression (P = .014), and presence of at least one APOE epsilon4 allele (P < .001) each independently predicted lower 3MSE score.
|
10522948 |
1999 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the association between depression and the genetic polymorphism of APOE in a large sample of depressed patients, Alzheimer's disease (AD) patients, and healthy controls following clear definitions for late-life depression.
|
10364642 |
1999 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the specificity of APOE genotyping in AD diagnosis would not appear to be compromised by an association with depression.
|
10910416 |
2000 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
APO-E may be a risk factor for cerebrovascular disease associated with late-life depression and may affect the clinical characteristics and disease course of depression.
|
10910427 |
2000 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with apolipoprotein E epsilon 4 were less likely to have psychotic forms of depression.
|
11722155 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the association between the APOE epsilon 4 polymorphism and the -491A/T and Th1E47csT/G polymorphisms in a sample of 118 healthy, non-demented controls and 239 consecutively recruited gerontopsychiatric patients diagnosed as: Alzheimer's disease (N = 89), age mild cognitive impairment (N = 32), memory complainers without any cognitive deficit (N = 54) and depression/other psychiatric disorders (N = 64), to test whether the investigated polymorphisms have a high enough selectivity and specificity to distinguish between the different gerontopsychiatric disorders or to differentiate AD genetically from other forms of dementia, respectively.
|
11315514 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For example, women generally appear at higher risk than men, as do people with lower levels of education; depression is probably prodromal; head injury is an established risk factor, and may interact with the apoE gene; several occupational exposures appear hazardous, and exposure to aluminum in the water supply confers excess risk.
|
11442298 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ninety-two community-dwelling elderly individuals participating in a study of white matter hyperintensities (WMHs) in normal aging whose apolipoprotein E (APOE) genotype had been determined completed the Geriatric Depression Scale and received an MRI scan.
|
11384894 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the apolipoprotein E epsilon4 allele with late-onset depression.
|
11684904 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E epsilon4 allele affects the relationship between stress and depression in caregivers of patients with Alzheimer's disease.
|
11563433 |
2001 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype and hippocampal volume change in geriatric depression.
|
11904138 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Possessing the APOE epsilon4 allele and depression did not enter either model significantly.
|
11939895 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the apolipoprotein E genotype and depression in Alzheimer's disease.
|
11936239 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.
|
12145452 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Forty-seven persons with depression (mean age=51.8 years, SD=12.4) and 20 healthy volunteers (mean age=56.1 years, SD=9.8) underwent clinical assessments, a neuropsychological test of psychomotor speed (part A of the Trail Making Test), high-resolution magnetic resonance imaging scans, and genotyping for the apolipoprotein E epsilon4 allele and a mutation of the methylenetetrahydrofolate reductase enzyme.
|
12450963 |
2002 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine if the APOE epsilon4 allele influences response in geriatric depression to mirtazapine and paroxetine, two frequently prescribed antidepressants.
|
14512205 |
2003 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, mean age-of-onset of depression in APOE4 carriers (51.4+/-20.7) was significantly lower than non-carriers (58.8+/-16.8).
|
14677138 |
2003 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein E gene (APOE) epsilon 4 allele has been associated with a variety of late-life neuropsychiatric disorders, including Alzheimer's disease, vascular dementia, and depression.
|
14512206 |
2003 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, there was a significant interaction effect of APOE and age such that the relationship of late-onset depression with respect to presence of the epsilon4 allele was larger among those 80 and older compared with those below age 80.
|
12701674 |
2003 |