Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest a protective role for APOE-ε2 allele to wet AMD in the Northern Spanish population.
|
31654486 |
2019 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Despite extensive genetic screening of candidate genes only two associations have been identified with AMD (Adenosine triphosphate (ATP)-binding cassette rim (ABCR) protein and apolipoprotein E gene-ApoE).
|
12700041 |
2003 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current study was conducted to investigate the association of Apolipoprotein E (ApoE) polymorphism with the treatment response to ranibizumab for exudative AMD.
|
26398858 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After controlling for age, gender, race, cigarette smoking, and other factors, early ARM was not associated with APOE genotypes, with an odds ratio (OR) of 1.35 (95% confidence interval [CI], 0.54-3.38) for epsilon2/epsilon2 genotype, an OR of 1.06 (95% CI, 0.80-1.40) for epsilon2/epsilon3 genotype, an OR of 0.63 (95% CI, 0.32-1.24) for epsilon2/epsilon4 genotype, an OR of 0.99 (95% CI, 0.80-1.24) for epsilon3/epsilon4 genotype, and an OR of 0.88 (95% CI, 0.47-1.63) for epsilon4/epsilon4 genotype, as compared with epsilon3/epsilon3 genotype (reference).
|
16406547 |
2006 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the potential association between 10 single nucleotide polymorphisms (SNPs) located in 4 different genetic regions (CFI, COL8A1, LIPC, and APOE), and choroidal neovascularization in age-related macular degeneration and the development of choroidal neovascularization in highly myopic eyes of a Caucasian population.
|
27643879 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
|
16453339 |
2006 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice.
|
25867331 |
2015 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study did not confirm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population.
|
25304313 |
2015 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the effect of TLR4, APOE and ABCA1 variants on AMD susceptibility was opposite to that of association with atherosclerosis risk.
|
15829498 |
2005 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we propose that ApoE serves a fundamentally different purpose in regulating cholesterol homeostasis in the retinal pigment epithelium and this could explain why allelic risk factors are flipped for AMD compared to Alzheimer's disease.
|
26427386 |
2016 |
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We show that subretinal MPs in AMD patients accumulate on the RPE and express high levels of APOE.
|
25604058 |
2015 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study.
|
22328704 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This lower relative frequency of the epsilon4 allele supports the hypothesis that the ApoE gene is a genetic protective factor identified in age-related macular degeneration.
|
9512153 |
1998 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
No significant association was observed between neovascular AMD and APOE or ELOVL4.
|
17210851 |
2007 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
How distinct APOE alleles affect AMD susceptibility warrants further investigation.
|
15111581 |
2004 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To date, of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease.
|
15111582 |
2004 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cholesterol efflux genes (APOE and ABCA1) were identified as risk factors for AMD, although how cholesterol efflux influences accumulation of this lipid in sub-RPE deposits remains elusive.
|
28973423 |
2017 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consistent with a pathogenic role for Aβ, we show here that a mouse model of AMD that invokes multiple factors that are known to modify AMD risk (aged human apolipoprotein E 4 targeted replacement mice on a high-fat, cholesterol-enriched diet) presents with Aβ-containing deposits basal to the retinal pigmented epithelium (RPE), histopathologic changes in the RPE, and a deficit in scotopic electroretinographic response, which is reflective of impaired visual function.
|
21690377 |
2011 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The CD subtype of AMD was significantly associated with current smoking as well as variants in the complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), complement factor B/complement component 2 (CFB/C2), complement component 3 (C3), and apolipoprotein E (APOE) genes.
|
22933840 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).
|
15059717 |
2004 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
A logistic model for early AMD found a significant association with AD diagnosis (p < 0.0001), after adjusting for confounders (age, smoking, hypertension, high and low density lipoproteins, cataract surgery and APOE ε4 carrier status).
|
27335042 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since single nucleotide polymorphism (SNP) rs405509:G>T is a constituent of the extended epsilon-haplotype block and is known to significantly influence APOE promoter activity, we hypothesize that both the relative rate of APOE isoform expression in conjunction with established functional differences of the respective isoforms may be crucial in mediating AMD pathology.
|
19384966 |
2009 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The individual effects on the risk of AMD for 18 of the 19 SNPs were in a consistent direction with those previously reported, including a protective effect of the APOE ε4 allele.
|
26176866 |
2015 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consistent with previous studies, the APOE epsilon2 allele is associated with a significant increased risk of late ARM development, whereas the epsilon4 allele may confer some protection.
|
17210854 |
2007 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that ApoE 4/2 genotype was less frequently observed in old patients (65 years and more) with exudative AMD compared to old healthy controls.
|
29851526 |
2018 |