|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This lower relative frequency of the epsilon4 allele supports the hypothesis that the ApoE gene is a genetic protective factor identified in age-related macular degeneration.
|
9512153 |
1998 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic association of apolipoprotein E with age-related macular degeneration.
|
9634502 |
1998 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Age-related macular degeneration (ARMD), characterized by drusen containing lipids, was reported to show a lower frequency of the ApoE epsilon4 allele than control subjects.
|
10859513 |
2000 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We compared AMD cases (n=230) to controls (n=372) with respect to APOE genotypes using c2 tests and logistic regression analysis.
|
11141572 |
2000 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E is a common component of the extracellular plaques and deposits characteristic of these disorders, including drusen, which are a hallmark of age-related macular degeneration.
|
11384575 |
2001 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The apoE gene polymorphism showed a significant association with the risk of AMD.
|
11721184 |
2002 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our studies on candidate genes of eye diseases in the Chinese population in Hong Kong include MYOC and TISR for primary open angle glaucoma, RHO and RP1 for retinitis pigmentosa, ABCA4 and APOE for age-related macular degeneration, RB1 for retinoblastoma, APC for familial adenomatous polyposis with congenital hypertrophy of retinal pigment epithelium, BIGH3/TGFBI for corneal dystrophies, PAX6 for aniridia and Reiger syndrome, CRYAA and CRYBB2 for cataracts, and mtDNA for Leber hereditary optic neuropathy.
|
11857735 |
2002 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data confirm that the APOE-4 allele, or an allele in linkage disequilibrium with it, reduces the risk of ARM.
|
12567264 |
2002 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Despite extensive genetic screening of candidate genes only two associations have been identified with AMD (Adenosine triphosphate (ATP)-binding cassette rim (ABCR) protein and apolipoprotein E gene-ApoE).
|
12700041 |
2003 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No evidence was found to support an association between AMD in medium to large families and the epsilon 4 or epsilon 2 alleles of APOE.
|
12742846 |
2003 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The findings are consistent with a role for apoE in lipid trafficking through Bruch's membrane and may be relevant to AMD.
|
14594998 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD).
|
15059717 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.
|
15111581 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
How distinct APOE alleles affect AMD susceptibility warrants further investigation.
|
15111581 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To date, of all the genes studied in relation to age-related macular degeneration (AMD), the alleles of the apolipoprotein (apoE) gene have been the most consistently associated with disease.
|
15111582 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To study the genotypes, allelic frequencies, and polymorphisms of apolipoprotein E (Apo E) in unrelated Japanese patients with polypoidal choroidal vasculopathy (PCV) or exudative age-related macular degeneration (AMD) and control subjects without macular degeneration.
|
15488782 |
2004 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the effect of TLR4, APOE and ABCA1 variants on AMD susceptibility was opposite to that of association with atherosclerosis risk.
|
15829498 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe here a murine model that combines three known AMD risk factors: advanced age, high fat cholesterol-rich (HF-C) diet, and apolipoprotein E (apoE) genotype.
|
16079201 |
2005 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The results show that APOE effects may be mediated early in the progression of ARM to AMD and thus may not be detected by standard genome scans for more severe disease.
|
16123405 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate whether APOE genotypes modify the smoking-associated risk of AMD.
|
16288198 |
2005 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After controlling for age, gender, race, cigarette smoking, and other factors, early ARM was not associated with APOE genotypes, with an odds ratio (OR) of 1.35 (95% confidence interval [CI], 0.54-3.38) for epsilon2/epsilon2 genotype, an OR of 1.06 (95% CI, 0.80-1.40) for epsilon2/epsilon3 genotype, an OR of 0.63 (95% CI, 0.32-1.24) for epsilon2/epsilon4 genotype, an OR of 0.99 (95% CI, 0.80-1.24) for epsilon3/epsilon4 genotype, and an OR of 0.88 (95% CI, 0.47-1.63) for epsilon4/epsilon4 genotype, as compared with epsilon3/epsilon3 genotype (reference).
|
16406547 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
|
16453339 |
2006 |
|
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
CTD_human |
Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).
|
16453339 |
2006 |
|
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation.
|
16823865 |
2006 |