|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Increased frequency of the apolipoprotein E-4 isoform in male subjects with multifactorial hypercholesterolemia.
|
4006269 |
1985 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
ApoE3 is considered the normal isoform, while apoE4 is associated both with hypercholesterolemia and type V hyperlipoproteinemia.
|
3745440 |
1986 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This finding indicates that APOE4 is associated with hypercholesterolemia in children.
|
2268973 |
1990 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition to our previous finding, this study indicates that hypercholesterolemia in apoE4-carrying NIDDM patients may be more closely related to poor metabolic control and increased percentage of ideal body weight.
|
2060414 |
1991 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we examined the levels of plasma lipids and apolipoproteins in patients with non-insulin dependent diabetes mellitus (NIDDM) with hypercholesterolemia in different apolipoprotein E (apo E) phenotypes.
|
8344125 |
1993 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Family studies failed to demonstrate cosegregation between the new mutations and severe hyperlipoproteinemia, although a number of carriers for the APOE*3(Cys112-->Arg; Arg251-->Gly) allele and the APOE*1(Arg158-->Cys; Leu252-->Glu) allele expressed hypertriglyceridemia and/or hypercholesterolemia.
|
8488843 |
1993 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia.
|
7825526 |
1995 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The analysis of cardiovascular risk factors showed that the risk of cognitive decline was highest in subjects with both APOE*4 and a high cholesterol level, high fibrinogen level, normal blood pressure, or diabetes mellitus.
|
8969786 |
1996 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus the structural differences between human APOE3 and mouse ApoE proteins are sufficient to cause an increased susceptibility to dietary-induced hypercholesterolemia and atherosclerosis in the 3/3 mice.
|
9218423 |
1997 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The only CVD risk factor that distinguished patients with the E4 allele from those with other apoE genotypes was elevated cholesterol.
|
9409270 |
1997 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size after middle cerebral artery occlusion (MCAO).
|
9721943 |
1998 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor.
|
9445249 |
1998 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Diabetic subjects with the apoE4 allele showed hypercholesterolemia, while those with apoE2 showed the presence of hypertriglyceridemia.
|
10741571 |
2000 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Adenovirus expressing apoE3 and apoE4 at doses of (1-2) x 10(9) pfu increased plasma cholesterol and triglyceride levels in normal C57BL6 mice and failed to normalize the high cholesterol levels of apoE-deficient mice due to induction of hypertriglyceridemia.
|
11352738 |
2001 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice.
|
11397713 |
2001 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To examine a long-term effect of community-based education program for hypercholesterolemia and an effect modification by apolipoprotein E polymorphism, we conducted a 1-year randomized clinical trial with 8 year-follow-up.
|
12119210 |
2002 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The risk for Alzheimer disease from treatable factors--elevated total cholesterol level and blood pressure--appears to be greater than that from the apoE epsilon4 allele.
|
12160362 |
2002 |
|
Hypercholesterolemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of apoE were fivefold higher in NS and in FSGS patients than in controls, with a direct correlation with hypercholesterolemia and proteinuria.
|
12631135 |
2003 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet exhibit a constellation of pathologies shared with human atherosclerotic coronary heart disease (CHD): hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarctions, cardiac dysfunction (heart enlargement, reduced systolic function and ejection fraction, and ECG abnormalities), and premature death (mean age 6 weeks).
|
12771386 |
2003 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Apolipoprotein E gene polymorphism, hypercholesterolemia and glomerular filtration rate in type 2 diabetic subjects: a 9-year follow-up study.
|
12595762 |
2003 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Hypercholesterolemia with statin use was associated with less risk of ICH (OR=0.30; P=0.0008) in multivariable analysis after controlling for alcohol use, hypertension, previous stroke, first-degree relative with ICH, education level, and apolipoprotein E alleles.
|
15087556 |
2004 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The combination of APOE epsilon4 with hypercholesterolemia or diabetes showed the greatest cognitive decline.
|
15668424 |
2005 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
APOE*4, TNFa 109, and DRB1*107 alleles were associated with increased relative risk for elevated total cholesterol to high-density lipoprotein (HDL) ratios.
|
15825968 |
2005 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The apolipoprotein E (ApoE) gene has been linked to maladies such as hypercholesterolemia, CNS injury and disease.
|
16091415 |
2005 |