|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Hypercholesterolemia with statin use was associated with less risk of ICH (OR=0.30; P=0.0008) in multivariable analysis after controlling for alcohol use, hypertension, previous stroke, first-degree relative with ICH, education level, and apolipoprotein E alleles.
|
15087556 |
2004 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Elevated cholesterol and APOE ϵ4 genotype are independent risk factors for cognitive decline in ART-adherent HIV(+) men aged >50 years.
|
27448678 |
2016 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K<sup>+</sup> Channels.
|
29502106 |
2018 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Apolipoprotein E gene polymorphism, hypercholesterolemia and glomerular filtration rate in type 2 diabetic subjects: a 9-year follow-up study.
|
12595762 |
2003 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
APOE*4, TNFa 109, and DRB1*107 alleles were associated with increased relative risk for elevated total cholesterol to high-density lipoprotein (HDL) ratios.
|
15825968 |
2005 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals.
|
16433808 |
2006 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-deficient mice, since their introduction in the early 1990s, have proved to be a very popular model for studying spontaneous hypercholesterolemia and the subsequent development of atherosclerotic lesions.
|
17007910 |
2006 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein-E/galectin-3 knockout mice were generated and fed a high-cholesterol "western" diet.
|
23426722 |
2013 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E gene polymorphisms in Lebanese with hypercholesterolemia.
|
23537987 |
2013 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-deficient (apoE(-/-) ) mice fed with a high-fat, high-cholesterol diet (HCD) and human umbilical vein endothelial cells (HUVECs) were used to explore the role of MNA in endothelial function and its underlying mechanism.
|
26887666 |
2016 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
APOE-e4 associated with a higher likelihood of hypercholesterolemia and overall illness index scores (ps < .05).
|
27486898 |
2016 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE genotypes were not associated with hypercholesterolemia.
|
30457419 |
2019 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice were fed a high-fat (60%) high-cholesterol (1%) diet (HFHCD) for 2 wk, followed by 6-wk 1% CLA 80:20 supplementation to investigate disease progression.
|
31284764 |
2019 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE ε4 allele is an established risk factor for Alzheimer's disease and hypercholesterolemia.
|
31677348 |
2019 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size after middle cerebral artery occlusion (MCAO).
|
9721943 |
1998 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A total of 100 unrelated children (6 +/-3 years old, 43 boys, 57 girls) with type IIa HC (LDLC >130 mg/dL) and complete genetic testing (at loci for genes for LDLR, apolipoprotein B, proprotein convertase subtilisin-like kesin type 9, and apolipoprotein E) were selected for score elaboration.
|
19330934 |
2009 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Adenovirus expressing apoE3 and apoE4 at doses of (1-2) x 10(9) pfu increased plasma cholesterol and triglyceride levels in normal C57BL6 mice and failed to normalize the high cholesterol levels of apoE-deficient mice due to induction of hypertriglyceridemia.
|
11352738 |
2001 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the available models, the apolipoprotein E-deficient (apoE⁻/⁻) mouse is of particular relevance because of its propensity to spontaneously develop hypercholesterolemia and atherosclerotic lesions that are similar to those found in humans, even when the mice are fed a chow diet.
|
22082357 |
2011 |
|
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An APOE variant was identified in three patients with isolated severe hypercholesterolemia giving a frequency of 1.3% in the cohort.
|
26802169 |
2016 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties.
|
21043830 |
2011 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
ApoE3 is considered the normal isoform, while apoE4 is associated both with hypercholesterolemia and type V hyperlipoproteinemia.
|
3745440 |
1986 |
|
Hypercholesterolemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
As a positive control, a doubling in genetically elevated cholesterol levels via apolipoprotein E associated with a hazard ratio of 6.3 (1.8-22) for all-cause mortality.
|
20423919 |
2010 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE.
|
22022523 |
2011 |
|
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice.
|
28205167 |
2017 |