|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size after middle cerebral artery occlusion (MCAO).
|
9721943 |
1998 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, when patients with at least one apoE4 allele and one X2 allele of apoB were combined and compared with those without either of them (E2E3 or E3E3 and X1X1), a significant association with the presence of cervical atherosclerosis was found (P = 0.03).
|
9667803 |
1998 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis.
|
9568731 |
1998 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the interaction of apolipoprotein E2(Arg158-Cys) (apoE2) and apolipoprotein E3-Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis.
|
9445249 |
1998 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, comparisons between the 2/2 and 3/3 mice unequivocally demonstrate that a single amino acid difference (Arg158 Cys) in the apoE protein is sufficient to cause type III HLP and spontaneous atherosclerosis in mice.
|
9649566 |
1998 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We previously found that compared to white subjects, the Inuit had a significantly increased prevalence of 4 candidate alleles for atherosclerosis-related phenotypes, namely AGT T235, FABP2 T54, PONI R192, and APOE E4, and a significantly decreased prevalence of 2 candidate alleles for atherosclerosis-related phenotypes, namely ACE D and MTHFR 677T.
|
9676056 |
1998 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the consequences of APOE epsilon 4 and atherosclerosis are not independent, and that particularly APOE epsilon 4 carriers with atherosclerosis are at increased risk of cognitive decline.
|
9700643 |
1998 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein E alleles epsilon2 and epsilon4 have been reported as independent risk factors for coronary artery disease (CAD) and as predictors for the development of atherosclerosis.
|
10583930 |
1999 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although the mechanisms underlying the effects of SR-BI loss on reproduction and atherosclerosis have not been established, potential causes include changes in (i) plasma lipoprotein levels and/or structure, (ii) cholesterol flux into or out of peripheral tissues (ovary, aortic wall), and (iii) reverse cholesterol transport, as indicated by the significant reduction of gallbladder bile cholesterol levels in SR-BI and SR-BI/apolipoprotein E double knockout mice relative to controls.
|
10430941 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both liver-derived and macrophage-derived apoEs have been shown to reduce plasma lipoprotein levels and slow the progression of atherosclerosis in apoE-deficient mice, but regression of atherosclerosis has not been demonstrated in this model.
|
10479659 |
1999 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apoE epsilon4 allele has been associated with advanced coronary heart disease (CHD) diagnosed by angiography, but the role of the apoE genotype in atherosclerosis has not been confirmed at vessel-wall level, nor is any age-dependent effect of the apoE genotype on the development of CHD known.
|
10441097 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.
|
10534277 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E and atherosclerosis in Greenland Inuit.
|
10428312 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol.
|
10407491 |
1999 |
|
Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High levels of atherosclerosis increased cognitive decline independently of APOE genotype.
|
10404910 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, immunization of transgenic atherosclerosis-prone mice (apolipoprotein E and low-density lipoprotein receptor knockouts) with human beta2-GPI results in a brisk and sustained respective response that extends to cross-react with the 'self' murine beta2-GPI.
|
10441168 |
1999 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, differences solely in apo E protein structure are sufficient to cause alterations in VLDL residence time and atherosclerosis risk in mice.
|
10359567 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increasing evidence from both animal and human studies suggests that apoE is able to protect against atherosclerosis by: a) promoting efficient uptake of triglyceride-rich lipoproteins from the circulation; b) maintaining normal macrophage lipid homeostasis; c) playing a role in cellular cholesterol efflux and reverse cholesterol transport; d) acting as an antioxidant; e) inhibiting platelet aggregation; and f) modulating immune function.
|
10511288 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
|
10484615 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
As a test model, we used these cells to deliver apolipoprotein E (apoE) in the murine apoE knockout atherosclerosis model.
|
10455419 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This appears to be mediated by an ApoE4-related increase in cardiovascular atherosclerosis.
|
10436099 |
1999 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis.
|
10984073 |
2000 |
|
Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Risk for arteriosclerosis is modulated by the apolipoprotein E (apoE) allele.
|
11096027 |
2000 |
|
Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Experimental investigation of the effects of these determinants on the development and progression of atherosclerosis has been greatly facilitated by the use of targeted mouse models of the disease, particularly those resulting from the absence of functional genes for apolipoprotein E or the low density lipoprotein receptor (LDLR).
|
11073835 |
2000 |