|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
APOE epsilon 4 allele is associated with cognitive impairment in patients with multiple sclerosis.
|
17460153 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common apoE alleles are in association with an increase in risk for central nervous and cardiovascular diseases such as Alzheimer's disease, dementia, multiple sclerosis, atherosclerosis, coronary heart disease, hyperlipoproteinemia and stroke.
|
17594534 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Studies examining the epsilon4 allele of the APOE gene as a factor affecting the severity of multiple sclerosis (MS) have yielded conflicting results.
|
17294608 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found an association of APOE epsilon4 with impaired verbal learning in patients with multiple sclerosis.
|
17310023 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the AA MS female patients who were APOE 4 carriers had an earlier age-of-onset and more severe disease course than CA MS female patients.
|
17254710 |
2007 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms.
|
17294608 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.
|
17376543 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association between apolipoprotein E and multiple sclerosis.
|
16796581 |
2006 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
While part of the association of the apoE polymorphism with AD is supposed to be caused by apoE-isoform dependent effects on amyloid-beta deposition, no single pathogenetically relevant mechanism has yet been confirmed for MS.
|
16631796 |
2006 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neuropsychological assessment, quantitative MRI and ApoE gene polymorphisms in a series of MS patients treated with IFN beta-1b.
|
16626758 |
2006 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To resolve these discrepancies, we examined common sequence variation in six candidate genes residing in a 380-kb genomic region surrounding and including the APOE locus for an association with MS severity.
|
16738668 |
2006 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association of apolipoprotein E epsilon4 genotype with faster progression or less recovery of relapses in a Spanish cohort of multiple sclerosis.
|
16459715 |
2006 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Pooled analyses of MS cases were also performed to assess the influence of APOE epsilon genotype on disease severity.
|
16682670 |
2006 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apo epsilon4 allele.
|
16193886 |
2005 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
To investigate the association between apolipoprotein E (Apo E) genotype in multiple sclerosis (MS) and acute monosymptomatic optic neuritis (ON) in a genetically homogeneous population with a high frequency of the Apo epsilon4 allele.
|
16193886 |
2005 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects.
|
15699400 |
2005 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In Kuwaitis, a population with low MS prevalence, no statistically significant associations between APOE genetic polymorphism and susceptibility to MS could be established, but there was a trend towards a lower APOE2 frequency with MS and towards increased frequency of APOE4 in female patients and with severe disease.
|
15563891 |
2005 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presence of significant NBV decreases only in the group of RRMS patients with the ApoE epsilon4 genotype provides new evidence that links ApoE epsilon4-related impaired mechanisms of cell repair and severe tissue destruction in MS.
|
15096402 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Apolipoprotein E (APOE)-epsilon4 has been associated with an unfavorable course of multiple sclerosis (MS).
|
15048896 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts.
|
15007140 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
APOE is also involved in several other neurodegenerative disorders, including Parkinson disease and multiple sclerosis.
|
15657798 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The relationship between ApoE and MPO genes' polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed.
|
15222689 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accelerated brain tissue loss and a higher proportion of lesions evolving into BH therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in MS patients with APOE-epsilon4.
|
15048896 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The telltale scan: APOE epsilon4 in multiple sclerosis.
|
15157846 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In order to test the previously proposed influence of the APOE and SCA2 loci on susceptibility to MS, we studied these loci in 243 Portuguese patients and 192 healthy controls and both parents of 92 patients.
|
15124760 |
2004 |