|
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct.
|
25555480 |
2015 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicate that analysis of IGHV gene usage might aid in predicting prognosis for FL patients.
|
25900812 |
2015 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of these, t(14;18)(q32;q21) results in juxtaposition of the IGH gene on chromosome 14 and the BCL2 gene on chromosome 18, leading to the overexpression of BCL2 anti-apoptotic protein, which plays a critical role in the development of follicular lymphoma (FL).
|
26115875 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular studies revealed clonal immunoglobulin heavy-chain (IGH) gene rearrangement within the HS, suggesting linkage to his previous B-ALL.
|
26574666 |
2015 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH.
|
25311808 |
2014 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In 50 cases of primary gastrointestinal MALT lymphoma (1) IGH arrangement was found in 59.5% of patients with primary gastrointestinal MALT lymphoma; IGH arrangement was found in 48.4% of patients with primary gastrointestinal MALT lymphoma at stage I-II and in 90.9% of patients at stage III-IV (χ(2) = 6.093, p < 0.05).
|
24272086 |
2014 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although these findings suggest that t(14;18)/IGH-MALT1 is a rare molecular event in gastrointestinal MALT lymphomas and DLBCLs, further studies to elucidate the role of this genetic alteration in these diseases are indicated.
|
24236896 |
2014 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease.
|
24030742 |
2014 |
|
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(8;14)(q24;q32) with juxtaposition of MYC to enhancer elements in the immunoglobulin heavy chain (IGH) gene locus is the genetic hallmark of the majority of Burkitt lymphoma and a subset of Diffuse large B-cell lymphoma patients.
|
23673335 |
2013 |
|
Lymphoma, Follicular
|
0.400 |
FusionGene
|
disease |
ORPHANET |
In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in FL of extraoral sites.
|
23953419 |
2013 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular lymphoma histologic grade in 255 follicular lymphoma patients who were treated with rituximab-containing therapy.
|
23916290 |
2013 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In Taiwan, FL3A tumours were more closely related to FL3B tumours than to LG tumours, and a literature review showed that the frequency of t(14;18)/IGH-BCL2 in FL in Taiwan is among the lowest in the world.
|
23631722 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, 12 (75%) patients with mucosal-associated lymphoid tissue lymphoma (n = 16) and 2 (40%) patients with diffuse large B-cell lymphoma (n = 5) were positive for monoclonal IgH gene rearrangements.
|
24039368 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MALT lymphomas were usually associated with a mutated IGHV gene, but with the absence of selection pressure.
|
22944768 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified several unbalanced aberrations and a t(11;14) involving IGH and DDX6 providing evidence for a contribution of DDX6 to lymphomagenesis by deregulation of BCL6 in NMZL.
|
22965301 |
2013 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin.
|
22431543 |
2012 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, pretreatment quantity of BCL2/IGH in PB or BM seems to mirror the extent of disease and can provide an auxiliary prognostic parameter in FL.
|
22381682 |
2012 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy-chain (IgH) gene, which is the molecular hallmark of FL, whereas a subset of cases harbor translocations involving the BCL6 gene locus.
|
22968395 |
2012 |
|
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A high Ki-67 proliferation index and positive bcl-2 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for c-MYC and/or IGH-BCL2 rearrangements to identify DHL, particularly if tissue biopsy is not expected.
|
21560252 |
2011 |
|
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have molecularly characterized the recently established Burkitt lymphoma cell line BLUE-1 that carries a t(6;20)(q15;q11.2) rearrangement in addition to the typical t(8;14) with MYC-IGH fusion.
|
21412927 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated.
|
21227398 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
The sequence analysis of the IgH gene revealed both of cells originated from the same clone, showing that the aggressive BL-like tumor originated from the FL-like clones simultaneously found in the bone marrow.
|
21184290 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens.
|
21497287 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL.
|
20952062 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas.
|
21790530 |
2011 |