|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, CC genotype of IL-1β and GG genotype of TNF-α have protective effect against myocardial infarction.
|
21380730 |
2011 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, IL-1 and IL-6 gene polymorphisms did not affect MI at younger age (MI<40) or older age (MI>40).
|
21199393 |
2011 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-6C and APOE epsilon4 alleles were independently associated with a mild or moderate increased risk of MI, whilst the allele C of the IL-1beta was not independently linked to MI risk.
|
15336915 |
2004 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study is to assess the modulatory effect of IL-1 genotypes on risk mediated by Lp(a) METHODS: We assessed whether IL-1 genotypes modulate the effect of Lp(a) on major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke/transient ischemic attack) and angiographically determined coronary artery disease (CAD).
|
29310992 |
2019 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL-1β-511C/T gene polymorphism may be related to the risk of MI complicated with IS.
|
30542472 |
2018 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-1 gene polymorphisms were found to play a role in the development of CAD, especially MI, in patients with CP infection.
|
11527622 |
2001 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HC shows the strongest effect on risk of MI in addition to HTN; gender and smoking status while drinking status shows protective effect on MI. rs16944 (gene IL-1β) and rs17222772 (gene ALOX) increase the risks of HC, while rs17231896 (gene CETP) has protective effects on HC either with or without the clinical, behavioral, demographic factors with different effect sizes that may indicate the existence of moderate or modifiable effects.
|
28906356 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found that MI triggered NLRP3 inflammasome activation leading to conversion of interleukin-1β (IL-1β) and IL-18 into their active mature forms in the heart, which could expand the infarct size and drive cardiac dysfunction.
|
31645662 |
2020 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.
|
11743230 |
2002 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac nerve sprouting after MI is associated in part with NF-κB activation in the PVN, and IL-1β is involved in the process.
|
31175933 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cases had higher levels of IL-1Ra at all time-points leading up to first-time MI, and higher levels of IL-1Ra were associated with approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation in order to reduce cardiovascular risk in PWH.
|
31077280 |
2020 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats.
|
23237935 |
2013 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data indicate that IL-1β-511TT/CC influence on the risk of myocardial infarction and ischemic stroke at young age through NF-κB, iNOS, MMP-2 and Bax.
|
26823694 |
2015 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-1β and Statin Treatment in Patients with Myocardial Infarction and Diabetic Cardiomyopathy.
|
31652822 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction.
|
15883752 |
2005 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.
|
30010800 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction.
|
16310260 |
2006 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Accordingly, CANTOS trial using an interleukin-1 beta antibody confirmed that inflammatory cytokines contribute to the occurrence of myocardial infarction and cardiac death independent of changes in lipids.
|
30918936 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Together, the data indicated that the knockdown of Mincle in microglia within the PVN prevents VAs by attenuating sympathetic hyperactivity and ventricular susceptibility, in part by inhibiting its downstream NLRP3/IL-1β axis following MI.
|
30353660 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, a recent Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial revealed the efficacy of IL-1β inhibition in preventing recurrent cardiovascular events in patients with MI.
|
30930410 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) showed that antagonism of interleukin (IL)-1β reduces coronary heart disease in patients with a previous myocardial infarction and evidence of systemic inflammation, indicating that pathways required for IL-1β secretion increase cardiovascular risk.
|
29588315 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, the CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study) showed the successful anti-inflammatory benefit of canakinumab, a monoclonal antibody targeting interleukin-1ß (IL-1ß) toward major cardiovascular events (MACE) in patients with a previous myocardial infarction (MI).
|
31469975 |
2020 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
All in all, miR-132 inhibits cardiomyocyte apoptosis so as to ameliorate myocardial remodeling in rats with MI through IL-1β downregulation.
|
31621911 |
2020 |