|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL-1β-511C/T gene polymorphism may be related to the risk of MI complicated with IS.
|
30542472 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-1β and Statin Treatment in Patients with Myocardial Infarction and Diabetic Cardiomyopathy.
|
31652822 |
2019 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A similar trend was identified for the expression of NF-κB, IL-1β and MMP-2, which was significantly increased in the MI group compared with that in the sham group (P<0.01), while it was significantly decreased in the MG and PDTC groups compared with that in the MI group (P<0.01).
|
30112065 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Accordingly, CANTOS trial using an interleukin-1 beta antibody confirmed that inflammatory cytokines contribute to the occurrence of myocardial infarction and cardiac death independent of changes in lipids.
|
30918936 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
All in all, miR-132 inhibits cardiomyocyte apoptosis so as to ameliorate myocardial remodeling in rats with MI through IL-1β downregulation.
|
31621911 |
2020 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
An association was observed between CAD and a common three-locus haplotype in the interleukin one (IL-1) cluster with P = 0.006 in all CAD cases, P = 0.01 in myocardial infarction (MI) cases and P = 0.0002 in young onset CAD cases (<50 years).
|
20070880 |
2010 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac nerve sprouting after MI is associated in part with NF-κB activation in the PVN, and IL-1β is involved in the process.
|
31175933 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cases had higher levels of IL-1Ra at all time-points leading up to first-time MI, and higher levels of IL-1Ra were associated with approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation in order to reduce cardiovascular risk in PWH.
|
31077280 |
2020 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy.
|
23143013 |
2013 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction.
|
16310260 |
2006 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of IL-1β are associated with adverse remodeling, and inhibition of IL-1 signaling after MI results in improved contractile function.
|
28111350 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats.
|
23237935 |
2013 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fifteen haplotype-tagging single nucleotide polymorphisms (SNPs) in the IL-1α (IL1A), IL-1β (IL1B), and IL-1 receptor antagonist (IL-1RN) genes were determined in the Health 2000 survey (n = 6771) and European myocardial infarction (MI) survivors (n = 972).
|
20178882 |
2010 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, a recent Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial revealed the efficacy of IL-1β inhibition in preventing recurrent cardiovascular events in patients with MI.
|
30930410 |
2019 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HC shows the strongest effect on risk of MI in addition to HTN; gender and smoking status while drinking status shows protective effect on MI. rs16944 (gene IL-1β) and rs17222772 (gene ALOX) increase the risks of HC, while rs17231896 (gene CETP) has protective effects on HC either with or without the clinical, behavioral, demographic factors with different effect sizes that may indicate the existence of moderate or modifiable effects.
|
28906356 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry and Western blotting showed that Minocycline reduced the expressions of inflammatory factors, NF-κB and IL-1β, etc., in myocardial cells after myocardial infarction.
|
29136949 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.
|
30010800 |
2018 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, IL-1 and IL-6 gene polymorphisms did not affect MI at younger age (MI<40) or older age (MI>40).
|
21199393 |
2011 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data indicate that IL-1β-511TT/CC influence on the risk of myocardial infarction and ischemic stroke at young age through NF-κB, iNOS, MMP-2 and Bax.
|
26823694 |
2015 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, these data highlight a key role for the IL-1R1/cardiac fibroblast signaling axis in regulating post-MI remodeling and provide support for the continued development of anti-IL-1 therapies for improving cardiac function after MI.
|
31393855 |
2019 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, CC genotype of IL-1β and GG genotype of TNF-α have protective effect against myocardial infarction.
|
21380730 |
2011 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammasome activation and IL-1β secretion are implicated in myocardial infarction (MI) and resultant heart failure; however, little is known about how macrophage lysosomes regulate these processes.
|
31672943 |
2019 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.
|
11743230 |
2002 |