|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-1 gene polymorphisms were found to play a role in the development of CAD, especially MI, in patients with CP infection.
|
11527622 |
2001 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.
|
11743230 |
2002 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-6C and APOE epsilon4 alleles were independently associated with a mild or moderate increased risk of MI, whilst the allele C of the IL-1beta was not independently linked to MI risk.
|
15336915 |
2004 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
-511C/T IL-1beta gene polymorphism affects the risk of MI and ischemic stroke at young age and the response of mononuclear cells to inflammatory stimulation.
|
15539626 |
2005 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction.
|
15883752 |
2005 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction.
|
16310260 |
2006 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
An association was observed between CAD and a common three-locus haplotype in the interleukin one (IL-1) cluster with P = 0.006 in all CAD cases, P = 0.01 in myocardial infarction (MI) cases and P = 0.0002 in young onset CAD cases (<50 years).
|
20070880 |
2010 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fifteen haplotype-tagging single nucleotide polymorphisms (SNPs) in the IL-1α (IL1A), IL-1β (IL1B), and IL-1 receptor antagonist (IL-1RN) genes were determined in the Health 2000 survey (n = 6771) and European myocardial infarction (MI) survivors (n = 972).
|
20178882 |
2010 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, IL-1 and IL-6 gene polymorphisms did not affect MI at younger age (MI<40) or older age (MI>40).
|
21199393 |
2011 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, CC genotype of IL-1β and GG genotype of TNF-α have protective effect against myocardial infarction.
|
21380730 |
2011 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy.
|
23143013 |
2013 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
RGD |
Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats.
|
23237935 |
2013 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data indicate that IL-1β-511TT/CC influence on the risk of myocardial infarction and ischemic stroke at young age through NF-κB, iNOS, MMP-2 and Bax.
|
26823694 |
2015 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of IL-1β are associated with adverse remodeling, and inhibition of IL-1 signaling after MI results in improved contractile function.
|
28111350 |
2017 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HC shows the strongest effect on risk of MI in addition to HTN; gender and smoking status while drinking status shows protective effect on MI. rs16944 (gene IL-1β) and rs17222772 (gene ALOX) increase the risks of HC, while rs17231896 (gene CETP) has protective effects on HC either with or without the clinical, behavioral, demographic factors with different effect sizes that may indicate the existence of moderate or modifiable effects.
|
28906356 |
2017 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry and Western blotting showed that Minocycline reduced the expressions of inflammatory factors, NF-κB and IL-1β, etc., in myocardial cells after myocardial infarction.
|
29136949 |
2018 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Transcript levels of the pro-inflammatory cytokines interleukin-6 and interleukin-1β were upregulated in hearts of vehicle treated animals compared to mice without MI.
|
29169754 |
2018 |
|
Myocardial Infarction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study is to assess the modulatory effect of IL-1 genotypes on risk mediated by Lp(a) METHODS: We assessed whether IL-1 genotypes modulate the effect of Lp(a) on major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke/transient ischemic attack) and angiographically determined coronary artery disease (CAD).
|
29310992 |
2019 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Systemic administration of 2-deoxyglucose after rodent MI normalized the hyperpolarized [1-<sup>13</sup>C]lactate signal in healing myocardial segments at day 3 and also caused dose-dependent improvement in IL (interleukin)-1β expression in infarct tissue without impairing the production of key reparative cytokines.
|
29440071 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) showed that antagonism of interleukin (IL)-1β reduces coronary heart disease in patients with a previous myocardial infarction and evidence of systemic inflammation, indicating that pathways required for IL-1β secretion increase cardiovascular risk.
|
29588315 |
2018 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
With the injection of neutralizing antibodies against IL-1β, control mice and MPGKO mice had comparable cardiac function and expression of inflammatory genes after MI.
|
29800789 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition.
|
30010800 |
2018 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A similar trend was identified for the expression of NF-κB, IL-1β and MMP-2, which was significantly increased in the MI group compared with that in the sham group (P<0.01), while it was significantly decreased in the MG and PDTC groups compared with that in the MI group (P<0.01).
|
30112065 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Together, the data indicated that the knockdown of Mincle in microglia within the PVN prevents VAs by attenuating sympathetic hyperactivity and ventricular susceptibility, in part by inhibiting its downstream NLRP3/IL-1β axis following MI.
|
30353660 |
2019 |