Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, IL-1β staining in MS brain tissue was much less pronounced.
|
27266875 |
2016 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis.
|
31231388 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients.
|
11498264 |
2001 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-1 (IL-1) is one of the major proinflammatory cytokines expressed consistently in multiple sclerosis (MS) lesions.
|
10685855 |
2000 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
However, in an in vitro inflammasome activity assay with PBMC, IL-1β protein secretion and the IL-1β/IL-1Ra protein ratio were similar in MS patients and HC.
|
25458313 |
2015 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The detected upregulation of IL1B in MS NAGM suggests inflammasome priming.
|
25937052 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings from the EAE model should inspire efforts toward investigating the therapeutic potential of IL-1 blockade in MS.
|
28583987 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.
|
15210533 |
2004 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fish oil is claimed to improve outcome in multiple sclerosis (MS) through anti-inflammatory and antioxidant effects by reducing cytokines including TNF-α, IFN-γ, IL6, and IL-1β.
|
29126030 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) is present in multiple sclerosis (MS) lesions.
|
12020968 |
2002 |
Multiple Sclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.
|
15210533 |
2004 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found for the IL-1β +3953 T allele [OR=1.43, 95% CI (1.14-1.79), P value=0.002, Pc=0.01] and for IL-1β +3953 T/T genotype and MS risk [OR=1.92, 95% CI (1.25-2.96), P value=0.005, Pc=0.01].
|
26531703 |
2015 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased IL-1β and IFN-γ and decreased IL-12 and IL-4 levels were found in progressive MS compared with RRMS.
|
27023227 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data suggest that the IL-1 cluster genes make no major contribution to MS, but the tentative association between IL-1RA allele 2 and susceptibility of MS in women warrants further studies.
|
11311293 |
2001 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the IL-1 region are not associated with MS risk but our data suggest that the IL-1ra VNTR polymorphism might be associated with bout-onset MS subtype.
|
23052182 |
2013 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistently, we found that cathepsin Z-deficiency reduced the efficiency of antigen presenting cells to secrete IL-1β, which in turn reduced the ability of mice to generate Th17 responses-critical steps in the pathogenesis of EAE and MS.
|
28486971 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis.
|
12775358 |
2003 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that compared with placebo, probiotic supplementation down-regulated gene expression of interleukin-8 (IL-8; p < 0.001) and tumor necrosis factor-alpha (TNF-α) mRNA (p < .001) in peripheral blood mononuclear cells of patients with MS. We did not observe any significant effect of probiotic supplementation on gene expression of interleukin-1 (IL-1), peroxisome proliferator-activated receptor gamma (PPAR-γ), or oxidized low-density lipoprotein receptor (LDLR) in peripheral blood mononuclear cells of patients with MS.
|
28922099 |
2018 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between IL-1 gene family and MS in the Turkish population.
|
23594042 |
2013 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, IL-1 plays a significant role in the regulation of the T-cells, and it is considered an essential cytokine for the Th cell differentiation that implicated in the MS pathogenesis.
|
22406096 |
2012 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS).
|
9413274 |
1997 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings support the existence of a causative variant for MS within this candidate region in a representative Italian Caucasian population and, in particular, the role of the IL-1 beta (-511 C/T) variant warrants further investigation.
|
20192980 |
2010 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The plasma levels of IL-1β, after treatment with IFN-β 1α, were significantly decreased in the MS patients.
|
27032392 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1β, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.
|
20876102 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis.
|
18322311 |
2008 |