Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients.
|
11498264 |
2001 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found for the IL-1β +3953 T allele [OR=1.43, 95% CI (1.14-1.79), P value=0.002, Pc=0.01] and for IL-1β +3953 T/T genotype and MS risk [OR=1.92, 95% CI (1.25-2.96), P value=0.005, Pc=0.01].
|
26531703 |
2015 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the IL-1 region are not associated with MS risk but our data suggest that the IL-1ra VNTR polymorphism might be associated with bout-onset MS subtype.
|
23052182 |
2013 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS).
|
9413274 |
1997 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings support the existence of a causative variant for MS within this candidate region in a representative Italian Caucasian population and, in particular, the role of the IL-1 beta (-511 C/T) variant warrants further investigation.
|
20192980 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis.
|
18322311 |
2008 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1 β), and tumor necrosis factor-α (TNF-α) are associated with Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
|
28856541 |
2018 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In data-sets derived from the Finnish population we found no evidence for contribution of the T-cell receptor beta chain (TCR beta chromosome 7q35), immunoglobulin heavy chain (IGH chromosome 14q32), interferon-gamma (IFN-gamma chromosome 12q14-q15) or interleukin-1 receptor antagonist/interleukin-1 beta (IL-1ra/IL-1 beta chromosome 2q14-q21) loci in the genetic susceptibility to MS.
|
9357444 |
1997 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hands, gain-of-function variants in NLRP3 (Q705K) and IL1B (-511 C >T) associated with severity and progression of MS, suggesting that a constitutive activation of NLRP3 inflammasome could represent a risk factor for MS clinical presentation.
|
30658261 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, IL-1β staining in MS brain tissue was much less pronounced.
|
27266875 |
2016 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis.
|
31231388 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
However, in an in vitro inflammasome activity assay with PBMC, IL-1β protein secretion and the IL-1β/IL-1Ra protein ratio were similar in MS patients and HC.
|
25458313 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings from the EAE model should inspire efforts toward investigating the therapeutic potential of IL-1 blockade in MS.
|
28583987 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.
|
15210533 |
2004 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fish oil is claimed to improve outcome in multiple sclerosis (MS) through anti-inflammatory and antioxidant effects by reducing cytokines including TNF-α, IFN-γ, IL6, and IL-1β.
|
29126030 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) is present in multiple sclerosis (MS) lesions.
|
12020968 |
2002 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data suggest that the IL-1 cluster genes make no major contribution to MS, but the tentative association between IL-1RA allele 2 and susceptibility of MS in women warrants further studies.
|
11311293 |
2001 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistently, we found that cathepsin Z-deficiency reduced the efficiency of antigen presenting cells to secrete IL-1β, which in turn reduced the ability of mice to generate Th17 responses-critical steps in the pathogenesis of EAE and MS.
|
28486971 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis.
|
12775358 |
2003 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between IL-1 gene family and MS in the Turkish population.
|
23594042 |
2013 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, IL-1 plays a significant role in the regulation of the T-cells, and it is considered an essential cytokine for the Th cell differentiation that implicated in the MS pathogenesis.
|
22406096 |
2012 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1β, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.
|
20876102 |
2010 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
One mechanism by which IL-1β might be involved in MS is by inducing pathogenic Th17 cells, i.e.GM-CSF+ Th17 cells.
|
25458313 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-1 (IL-1) is implicated in numerous pathologies, including multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE).
|
27827809 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI -511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility to and the clinical characteristics in Greek multiple sclerosis (MS) patients cohort with bout-onset.
|
19876593 |
2010 |