|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) is present in multiple sclerosis (MS) lesions.
|
12020968 |
2002 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis.
|
18322311 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found for the IL-1β +3953 T allele [OR=1.43, 95% CI (1.14-1.79), P value=0.002, Pc=0.01] and for IL-1β +3953 T/T genotype and MS risk [OR=1.92, 95% CI (1.25-2.96), P value=0.005, Pc=0.01].
|
26531703 |
2015 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and secretion of IL-1β and IL-18 and, thus, plays a key role in the pathogenesis of many inflammatory conditions, including multiple sclerosis (MS).
|
31736980 |
2019 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis.
|
10814801 |
2000 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, IL-1β staining in MS brain tissue was much less pronounced.
|
27266875 |
2016 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the IL-1 region are not associated with MS risk but our data suggest that the IL-1ra VNTR polymorphism might be associated with bout-onset MS subtype.
|
23052182 |
2013 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistently, we found that cathepsin Z-deficiency reduced the efficiency of antigen presenting cells to secrete IL-1β, which in turn reduced the ability of mice to generate Th17 responses-critical steps in the pathogenesis of EAE and MS.
|
28486971 |
2017 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.
|
15210533 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Different effects of simvastatin and interferon beta on the proteolytic activity of matrix metalloproteinases.
|
15210533 |
2004 |
|
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, we confirm a Nlrp3 inflammasome signature and IL-1β expression in brain and cerebrospinal fluid from MS patients.
|
29789522 |
2018 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fish oil is claimed to improve outcome in multiple sclerosis (MS) through anti-inflammatory and antioxidant effects by reducing cytokines including TNF-α, IFN-γ, IL6, and IL-1β.
|
29126030 |
2017 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients.
|
11498264 |
2001 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Given that SAA is detected in Alzheimer disease and multiple sclerosis brain, together with IL-1β-immunopositive microglia, these findings propose a link between P2X<sub>7</sub>R, SAA, and IL-1β in CNS pathophysiology.
|
29803222 |
2018 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1β, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients.
|
20876102 |
2010 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we review the recent findings showing an implication of the IL-1 system in EAE and MS, and introduce a model that highlights how IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF) are interacting together to create a vicious feedback cycle of CNS inflammation that ultimately leads to myelin and neuronal damage.
|
27432634 |
2017 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
However, in an in vitro inflammasome activity assay with PBMC, IL-1β protein secretion and the IL-1β/IL-1Ra protein ratio were similar in MS patients and HC.
|
25458313 |
2015 |
|
Multiple Sclerosis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
However, in an in vitro inflammasome activity assay with PBMC, IL-1β protein secretion and the IL-1β/IL-1Ra protein ratio were similar in MS patients and HC.
|
25458313 |
2015 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we observed no significant effect of the polymorphisms on brain or lesion volumes, Based on our data and those from the literature, one can conclude that there is currently no evidence to support a role for the IL-1 genes in MS.
|
14664464 |
2003 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In data-sets derived from the Finnish population we found no evidence for contribution of the T-cell receptor beta chain (TCR beta chromosome 7q35), immunoglobulin heavy chain (IGH chromosome 14q32), interferon-gamma (IFN-gamma chromosome 12q14-q15) or interleukin-1 receptor antagonist/interleukin-1 beta (IL-1ra/IL-1 beta chromosome 2q14-q21) loci in the genetic susceptibility to MS.
|
9357444 |
1997 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present work, we overexpressed interleukin 1 beta (IL-1β) in the cortex to develop an animal model reflecting the main pathological hallmarks of MS.
|
29378262 |
2018 |
|
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased IL-1β and IFN-γ and decreased IL-12 and IL-4 levels were found in progressive MS compared with RRMS.
|
27023227 |
2017 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1 β), and tumor necrosis factor-α (TNF-α) are associated with Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
|
28856541 |
2018 |
|
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the levels of IL-1β (-0.5961 ± 0.265) were lower in the MS cohort.
|
29615953 |
2018 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis.
|
12775358 |
2003 |