|
Acquired aplastic anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
CD4(+)CD25(+) regulatory T cells (Tregs) were believed to control development and progression of autoimmunity by suppressing autoreactive effector T cells, but little was known regarding the function of Tregs in AA.
|
22797698 |
2012 |
|
Acquired aplastic anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recently enhanced T-helper type 17 (Th17) immune responses and deficient CD4(+) CD25(hi) FoxP3(+) regulatory T cells (Tregs) have been reported in acquired aplastic anemia (AA).
|
25784172 |
2015 |
|
Acquired aplastic anemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.
|
17463169 |
2007 |
|
Acquired Hypogammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: a link to autoimmunity?
|
19394278 |
2009 |
|
Acquired Hypogammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Frequency and expression of inhibitory markers of CD4(+) CD25(+) FOXP3(+) regulatory T cells in patients with common variable immunodeficiency.
|
23432692 |
2013 |
|
Active tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels.
|
17299718 |
2007 |
|
Acute anterior uveitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here the role of two IL2RA gene variants (rs11594656 and rs12722495) was investigated in intermediate uveitis and HLAB27 acute anterior uveitis.
|
26133380 |
2015 |
|
Acute anterior uveitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study suggests that FoxO1, but not miR-27a, miR-182, and IL2RA, contributes to the genetic susceptibility of AAU with AS, but none of the tested polymorphisms confer risk to AAU without AS.
|
25414190 |
2014 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, up-regulation of DNA-methyltransferases was detected in CD4(+)CD25(+) Tregs obtained from ACS patients as compared to those from normal coronary controls.
|
23566804 |
2013 |
|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The in vivo role of phebestin-exposed CD4+CD25+ T-cells was studied in sodium dextran sulfate-induced acute colitis in mice.
|
17786278 |
2007 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The spontaneous apoptosis of Treg cells (defined as CD4(+)CD25(+)CD127(low)annexin V(+)7-AAD(-)) was increased in the NSTACS patients compared with the CSA and CPS groups.
|
22872639 |
2012 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Changes of naturally occurring CD4(+)CD25(+) FOXP3(+) regulatory T cells in patients with acute coronary syndrome and the beneficial effects of atorvastatin treatment.
|
25740578 |
2015 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, elevated frequencies of donor CD8+CD25+ T cells showed significant correlations with grade II-IV acute GvHD.
|
16219576 |
2005 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
The conditioning regimen consisted of fludarabine, cyclophosphamide and busulfan, and prophylaxis of acute graft-versus-host disease (GvHD) was performed by administration of anti-CD25 monoclonal antibody, cyclosporine A, methotrexate, mycophenolate mofetil and anti-thymocyte globulin.
|
20380540 |
2010 |
|
Acute GVH disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Regulatory T cells (Tregs) (CD4+CD25(high) Foxp3+) are believed to maintain tolerance and to inhibit acute GVHD (aGVHD) after allogeneic PBSCT.
|
23200706 |
2013 |
|
Acute infectious disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Infants suffering acute infection showed marginally higher levels of membrane CD25 expression than infants without overt infection.
|
9757943 |
1998 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
The consistent association of CD25 in cases of t(9;22) ALL indicated that CD25 could be used as a surrogate marker.
|
29237973 |
2018 |
|
Acute lymphocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The pre-B Reh-6 leukemic cells do not express membrane interleukin-2 (IL-2)-R alpha (Tac or p55) chain; however, their incubation with PMA induces the expression of both high and low affinity IL-2-R. Northern analysis of nonstimulated Reh-6 as well as leukemic cells from patients with acute B cell precursor lymphoblastic leukemia displayed a constitutive expression of p55 mRNA transcripts, which could be enhanced by PMA.
|
2243505 |
1990 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
IL2-TRAIL fusion protein was highly specific for CD25+ leukemia and showed 100 % efficacy in lymphocytic leukemia [acute lymphoblastic leukemia and chronic lymphocytic leukemia] that overexpressed CD25.
|
26984209 |
2016 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, CD25 expression may serve as a surrogate marker for BCR/ABL positivity (Philadelphia chromosome), the major poor prognostic parameter in adult ALL.
|
9369422 |
1997 |
|
Acute lymphocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
CD25 (IL-2RA) and CD26 (DPPIV) were expressed on LSCs in Ph<sup>+</sup> ALL exhibiting BCR/ABL1<sub>p210</sub>, whereas in Ph<sup>+</sup> ALL with BCR/ABL1<sub>p190</sub>, LSCs variably expressed CD25 but did not express CD26.
|
29772458 |
2018 |
|
Acute monocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML.
|
30550585 |
2018 |
|
Acute monocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of CD25 on HSC (CD34<sup>+</sup>CD38<sup>-</sup> cells) in MDS patients (28.81%) was significantly higher than that in normal controls (9.41%, P = 0.020), which similar to that in AML patients (32.54%, P = 0.410).
|
29407181 |
2018 |
|
Acute monocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900.
|
22855599 |
2012 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased Circulating CD4+CD25+CD127low/neg Regulatory T-cells as a Prognostic Biomarker in Acute Pancreatitis.
|
28787335 |
2017 |