|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to analyze early and late activation of T-lymphocytes related to Epstein-Barr virus (EBV) infection by the expression of markers of activation (CD69, CD25) on the surface of T-lymphocytes (CD3<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup>) in patients bearing laryngeal cancer according to absence/presence immunoglobulin G antibodies to EBV nuclear antigen (EBNA1).
|
31662531 |
2020 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to analyze early and late activation of T-lymphocytes related to Epstein-Barr virus (EBV) infection by the expression of markers of activation (CD69, CD25) on the surface of T-lymphocytes (CD3<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup>) in patients bearing laryngeal cancer according to absence/presence immunoglobulin G antibodies to EBV nuclear antigen (EBNA1).
|
31662531 |
2020 |
|
PARKINSON DISEASE, LATE-ONSET
|
0.010 |
Biomarker
|
disease |
BEFREE |
RT-qPCR validation showed higher expression of <i>CD24</i> (CD24 molecule), <i>LY9</i> (lymphocyte antigen 9), <i>TNFRSF4</i> (tumor necrosis factor receptor superfamily, member 4), <i>CD79A</i> (CD79a molecule, immunoglobulin-associated alpha), <i>CCR7</i> (chemokine (C-C motif) receptor 7), <i>CEACAM1</i> (carcinoembryonic antigen-related cell adhesion molecule 1) and IL2RA (interleukin 2 receptor, alpha) in long-term PD patients, <i>CD24</i> having the best discrimination ability between short- and long-term treatment.
|
31760769 |
2020 |
|
Chronic osteomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-2/STAT5/CD4+CD25+Foxp3 Treg pathway may be involved in the pathogenesis of COM, and excessive immunosuppression may lead to persistent infectious inflammation, which may become a key target for future treatment of COM.
|
31555698 |
2019 |
|
Furunculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Due to the lack of reports on PD-1- and PD-L1-positive lymphocyte proportions in patients with recurrent furunculosis, we aimed to evaluate percentages of those cells in the peripheral blood and to assess their correlations with other lymphocyte subsets, and the level of cell activation measured by the expression of CD25 and CD69 molecules on T lymphocytes.
|
30342909 |
2019 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
All of the mice demonstrated similar levels of CD4+ T-cell proliferation following direct T-cell receptor stimulation, but we detected splenic IL-33 and ST2-negative Foxp3+CD4+CD25+ T cells in ST2-/- mice that developed less hepatitis than BALB/c mice (p < 0.05), suggesting that ST2-negative Foxp3+CD4+CD25+ T cells reduced hepatitis.
|
30030493 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the CD4+CD25+TIM-3+ T cells from both healthy controls and AKI patients presented higher capacity to suppress CD4+CD25- T cell proliferation than the CD4+CD25+TIM-3- T cells.
|
29985717 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.
|
31440043 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests that anomalous activation of ovarian macrophages and numerical and functional deficits in the Th17 (CD4+IL17A+) and the CD4+CD25+CD127<sup>low</sup> Tregs plays crucial role in PCOS.
|
31024070 |
2019 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Seven mAbs were associated with a significantly increased odds of psychosis (OR = 1.42-2.22), including two agents that target CD25.
|
31170448 |
2019 |
|
Sialadenitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RORγt antagonist improves Sjögren's syndrome-like sialadenitis through downregulation of CD25.
|
31837283 |
2019 |
|
Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study.
|
29506265 |
2019 |
|
Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-33 is an innate, IL-4-inducing, Th2-polarizing cytokine that has been detected in patients with liver failure and has been associated with upregulated ST2+Foxp3+CD4+CD25+ T cells; however, roles for IL-33 in drug-induced hepatitis are unclear.
|
30030493 |
2019 |
|
Oral Ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD4+CD25+CD127dim levels showed significant association with alopecia and oral ulcers in SLE patients only, but no correlation with measured serum markers.
|
30325682 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CPEB2KO, but not wild-type cells produced lung colonies upon intravenous injection and subcutaneous tumors and spontaneous lung metastases upon implantation at mammary sites in NOD/SCID/IL2Rϒ-null mice, identified with HLA immunostaining.
|
31185986 |
2019 |
|
Prurigo nodularis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aprepitant treatment showed significant reduction in pruritus intensity (P < 0.05) in PN and relevant immunohistochemical changes (down: CD5, CD25, up: CD79a, IL4).
|
31442331 |
2019 |
|
recurrent cutaneous T-cell lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Denileukin diftitox (DAB-IL-2, Ontak) is a diphtheria-toxin-based fusion protein that depletes CD25-positive cells including regulatory T cells and has been approved for the treatment of persistent or recurrent cutaneous T cell lymphoma.
|
30718426 |
2019 |
|
Nonorganic psychosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seven mAbs were associated with a significantly increased odds of psychosis (OR = 1.42-2.22), including two agents that target CD25.
|
31170448 |
2019 |
|
Allergy to peanuts
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mice were intraperitoneally injected with anti-CD25 antibodies for regulatory T cell (Treg) depletion to evaluate the efficacy of Tregs in preventing peanut allergy.
|
31468633 |
2019 |
|
Stage IV Lung Cancer AJCC v7
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDH1 (encoding the epithelial cell marker E-cadherin) and IL2RA (encoding the Treg marker CD25) expression in patients with stage IV lung cancer that were resistant to cisplatin treatment showed an inverse correlation between IL2RA (high) and CDH1 (low) expression.
|
31066485 |
2019 |
|
Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Then, we studied the association of ATG (vs. IL2RA) with KT outcomes (rejection, graft failure, and death) and hepatic complications (liver transplant registration and cirrhosis) among HCV+ recipients using logistic and Cox regression.
|
31568217 |
2019 |
|
HCV coinfection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-).
|
30944340 |
2019 |
|
Stage IV Lung Cancer AJCC v6
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDH1 (encoding the epithelial cell marker E-cadherin) and IL2RA (encoding the Treg marker CD25) expression in patients with stage IV lung cancer that were resistant to cisplatin treatment showed an inverse correlation between IL2RA (high) and CDH1 (low) expression.
|
31066485 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The predictive and prognostic value of Foxp3+/CD25+ regulatory T cells and PD-L1 expression in triple negative breast cancer.
|
31096176 |
2019 |
|
Immune-mediated hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The complete absence of IL-33 reduced IL-10 (p < 0.05) and ST2+Foxp3+CD4+CD25+ T cells (p < 0.05), as well as reduced the overall survival (p < 0.05), suggesting suppressive roles for IL-33 in anesthetic, immune-mediated hepatitis.
|
30030493 |
2019 |