|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis.
|
26819262 |
2016 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation.
|
20179739 |
2010 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It was concluded that both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to MS.
|
22117963 |
2011 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together these results confirm involvement of polymorphisms in the IL7RA and IL2RA genes in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses.
|
19231135 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both signals in the two variant model for MS affect CD25 expression on distinct subpopulations of CD4+ T cells, which are key cells in the autoimmune process.
|
26106896 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that gene expression in peripheral blood mononuclear cells (PBMCs) from healthy controls (HCs) and MS patients are associated with IL2RA SNP rs2104286 and that gene expression levels correlate with soluble CD25 (sCD25) concentrations - that are affected by rs2104286.
|
28511943 |
2017 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12).
|
19834503 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis aims to evaluate the relationship of the IL2RA polymorphisms rs2104286 and rs12722489 with MS risk in different populations.
|
29648897 |
2018 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An effect of the IL2RA and CD58 loci was shown in multiplex families as in sporadic MS.
|
19506219 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
|
18354419 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified an association between two intronic single nucleotide polymorphisms (SNPs), rs12722489 and rs2104286, in the interleukin-2 receptor alpha-chain gene (IL2RA) and susceptibility to multiple sclerosis (MS).
|
21239413 |
2011 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of these SNPs, two within the interleukin-2 receptor alpha gene (IL2RA) were strongly associated with multiple sclerosis (P=2.96x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81)).
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
|
18354419 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?
|
21911588 |
2011 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL2RA variants are known to protect against multiple sclerosis, diabetes mellitus and RA.
|
26350950 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, similar to MS, the MGAT1 variant haplotype interacted with CTLA4 (P=0.03), and a combination of IL2RA and IL7RA (P=0.01).
|
24572742 |
2014 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 may increase the onset risk of MS. IL2RA-rs2104286 showed a positive relationship with CXCR5-rs3922.
|
30352019 |
2018 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles.
|
19375175 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
|
26765264 |
2016 |