|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study investigates the expression of T cell receptor V delta 1 chain, interleukin-2 receptor alpha-chain (CD25) and adhesion molecules ICAM-1 (CD54), LFA-1 (CD11a/18) and CD44 on gamma delta+ T cells by three-color flow cytometry on cerebrospinal fluid (CSF) and blood cells in patients with multiple sclerosis (MS), other inflammatory neurological diseases (OIND) and other neurological diseases (OND).
|
7507498 |
1994 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Examination of activated T cells (CD3+CD25+) isolated from the peripheral blood of MS revealed limited numbers (20 approximately 82) of expanded clones defined by single-strand conformation polymorphism clonotype.
|
9973446 |
1999 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells.
|
15788534 |
2005 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied whether changes in the suppressive function of a mixture of CD25(high) and CD25(intemediate) expressing T(reg) cells in myelin basic protein (MBP)-induced proliferation occurred in untreated MS patients.
|
17011048 |
2006 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of these SNPs, two within the interleukin-2 receptor alpha gene (IL2RA) were strongly associated with multiple sclerosis (P=2.96x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81)).
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
|
18354419 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
|
18354419 |
2008 |
|
Multiple Sclerosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The down-regulated 4-1BB expression on CD4+CD25(high) Tregs of MS patients may be involved in the impaired immunoactivity of these Tregs.
|
18727631 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide study showed three additional single-nucleotide polymorphisms (SNPs), within the IL2RA and IL7RA genes respectively, also to be associated with MS.
|
18401352 |
2008 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.
|
18650830 |
2008 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, large international collaborations provided strong evidence for the involvement of polymorphism of two cytokine receptor genes in the pathogenesis of MS: the interleukin 7 receptor alpha chain gene (IL7RA) on chromosome 5p13 and the interleukin 2 receptor alpha chain gene (IL2RA (=CD25)) on chromosome 10p15.
|
18461312 |
2008 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together these results confirm involvement of polymorphisms in the IL7RA and IL2RA genes in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses.
|
19231135 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine whether percentages of CD4(+)CD25(high) T cells (a group of regulatory T cells, Treg) differ in patients with multiple sclerosis (MS) in relapse vs remission after glucocorticoid treatment and whether treatment for relapses changes Treg population and the expression of Foxp3, a key Treg-associated molecule.
|
18771523 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12).
|
19834503 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we use polychromatic flow cytometry to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases, type 1 diabetes (T1D) and multiple sclerosis.
|
19701192 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The population of CD4(+)CD25(+) Tregs was decreased in acute stage of MS.
|
19539557 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An effect of the IL2RA and CD58 loci was shown in multiplex families as in sporadic MS.
|
19506219 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional investigations suggest a potential mechanism whereby increases in CD58 expression, mediated by the protective allele, up-regulate the expression of transcription factor FoxP3 through engagement of the CD58 receptor, CD2, leading to the enhanced function of CD4(+)CD25(high) regulatory T cells that are defective in subjects with MS.
|
19237575 |
2009 |