|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis.
|
26819262 |
2016 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study investigates the expression of T cell receptor V delta 1 chain, interleukin-2 receptor alpha-chain (CD25) and adhesion molecules ICAM-1 (CD54), LFA-1 (CD11a/18) and CD44 on gamma delta+ T cells by three-color flow cytometry on cerebrospinal fluid (CSF) and blood cells in patients with multiple sclerosis (MS), other inflammatory neurological diseases (OIND) and other neurological diseases (OND).
|
7507498 |
1994 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation.
|
20179739 |
2010 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A.
|
22130326 |
2012 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although the possibility that IL2RA is a risk factor for MS development was not confirmed in this Japanese population, IL2RA gene polymorphisms were able to modify the disease activity in female MS patients, but had no influence on either susceptibility or disease phenotype in NMO/NMOSD patients.
|
24332945 |
2014 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk factors for multiple sclerosis (MS).
|
21716315 |
2012 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It was concluded that both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to MS.
|
22117963 |
2011 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association between IL2RA and MS is clearly established, although the functional variation is still unknown: the effect of IL2RA might be better described by several SNPs than by a single one.
|
22085902 |
2012 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together these results confirm involvement of polymorphisms in the IL7RA and IL2RA genes in MS pathogenesis and suggest that IL7RA variation may primarily affect chronic disease courses.
|
19231135 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine whether percentages of CD4(+)CD25(high) T cells (a group of regulatory T cells, Treg) differ in patients with multiple sclerosis (MS) in relapse vs remission after glucocorticoid treatment and whether treatment for relapses changes Treg population and the expression of Foxp3, a key Treg-associated molecule.
|
18771523 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both signals in the two variant model for MS affect CD25 expression on distinct subpopulations of CD4+ T cells, which are key cells in the autoimmune process.
|
26106896 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that gene expression in peripheral blood mononuclear cells (PBMCs) from healthy controls (HCs) and MS patients are associated with IL2RA SNP rs2104286 and that gene expression levels correlate with soluble CD25 (sCD25) concentrations - that are affected by rs2104286.
|
28511943 |
2017 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12).
|
19834503 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we use polychromatic flow cytometry to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases, type 1 diabetes (T1D) and multiple sclerosis.
|
19701192 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis aims to evaluate the relationship of the IL2RA polymorphisms rs2104286 and rs12722489 with MS risk in different populations.
|
29648897 |
2018 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Flow cytometry was used to study the activation of CD4+ T cells and T cell subsets (CD25(high) and CD26(high) cells), monocytes and DCs in a cross-sectional study of 39 untreated and 29 GA-treated MS patients, the latter followed prospectively for one year.
|
22653658 |
2013 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The population of CD4(+)CD25(+) Tregs was decreased in acute stage of MS.
|
19539557 |
2009 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
|
21300823 |
2011 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Multiple Sclerosis
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Our data suggest that differential methylation of the IL2RA promoter in T cells could be an important pathogenic mechanism in MS.
|
28077880 |
2017 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An effect of the IL2RA and CD58 loci was shown in multiplex families as in sporadic MS.
|
19506219 |
2009 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
|
18354419 |
2008 |