|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results indicate that in females the TLR4 and IL4 genes show an epistatic effect on the risk of asthma.
|
16215326 |
2005 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The relative levels of miR-126 and IL-4 and the Th17 cell percentage were positively correlated with the severity of the asthma, while IFN-γ levels and the CD4<sup>
|
29809062 |
2018 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL4-590*CT/TT and IL4-RP2*253183/183183 were found to predict the risk (2-fold) and severity (3 to 4-fold) of asthma and were associated with a lower FEV1 index.
|
25299150 |
2014 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-4 is believed to perform important regulatory roles in asthma; however, the expression of the IL-4 receptor has not been investigated.
|
9819306 |
1998 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings provide support for the view that both chromosomes 5 and 11 may contain genes relevant to asthma and atopy, a possible candidate being the interleukin-4 (IL-4) gene cluster.
|
8616554 |
1996 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
RGD |
TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs.
|
21364926 |
2011 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interestingly, these differences clustered in the genes highly associated with asthma (ORMDL family) and IgE regulation (RAD50, IL13, and IL4), but not in the T-regulatory genes (FOXP3, RUNX3).
|
23346934 |
2013 |
|
Asthma
|
0.600 |
Therapeutic
|
disease |
RGD |
After the treatment, changes of EOS in peripheral blood of asthma rats were observed; enzyme linked immunosorbent assay (ELISA) was applied to test the contents of IgE, IL-4 and IFN-gamma in the lung tissue; real-time Q-PCR method was adopted to measure the expression level of transcription factor T-bet and GATA binding protein 3 (GATA-3) in the lung tissue.
|
24946644 |
2014 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We propose that: (i) IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and (ii) by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.
|
15677460 |
2005 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Biologics targeting IL-5, IL-4 or IL-13 for the treatment of asthma - an update.
|
27459348 |
2017 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients with asthma in whom the mucus score was high had raised Feno (P = .03) and IL-4 (P = .02) values.
|
30910637 |
2019 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma.
|
11398072 |
2001 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
When both IL-4 and IL-5 were neutralized in this system, AHR was still induced, suggesting that influenza-induced cytokines such as IL-13, or mechanisms unrelated to cytokines, might be responsible for the development of AHR.
|
10975869 |
2000 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggest that when activated by IL-4 and IL-13, different subsets of lung fibroblasts may act as effector cells not only in the pathogenesis of asthma but also in lung remodeling processes.
|
9593769 |
1998 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa.
|
8564096 |
1996 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Their Global Initiative for Asthma⁻based asthma severity, Childhood Asthma Control Test (C-ACT) scores, Pediatric Asthma Severity Scores, Pediatric Asthma Quality of Life Questionnaire scores, peak expiratory flow rates (PEFRs), medication use, the levels of immune biomarkers (immunoglobulin E (IgE), interferon γ, interleukin 4, and tumor necrosis factor α) at different visits, and the associated changes were evaluated.
|
30400588 |
2018 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These results indicate a possible involvement of SNPs in the IL4 gene in the development of asthma and the regulation of total serum IgE.
|
14610476 |
2003 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared with the asthma group, the IL-4R group had relatively regular tissue structure and light inflammation, declined maximal RL, numbers of total cells, EOS, neutrophils, and lymphocytes, contents of IgE, IL-4, IL-5 and IL-13, percentages of IFN-γ<sup>+</sup> CD4<sup>+</sup> and IFN-γ<sup>+</sup>/IL-4<sup>+</sup> in total T cells, mRNA expressions of IL-4, IL-5, IL-13, STAT6, pSTAT6, SOCS, iNOS and VCAM-1, and protein expressions of STAT6 and pSTAT6, but elevated IFN-γ content and percentage of IL-4<sup>+</sup> CD4<sup>+</sup> in total T cells.
|
28093225 |
2017 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin.
|
27534531 |
2016 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the relationships among IL-4, TRPC1 and mucus overproduction in bronchial epithelial cells (BECs) in asthma are poorly understood.
|
28931396 |
2017 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, administration of the IL-18 Adv to mice with established AHR greatly reduced AHR and IL-4 production and increased IFN-gamma production.
|
11342664 |
2001 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis.
|
30995510 |
2019 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL13, rather than RAD50, IL4, or IL5, is more likely to be the asthma susceptibility gene.
|
27050946 |
2016 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.
|
29182669 |
2017 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, it promoted the occurrence and development of asthma by influencing the expression levels of IL-7 and various relevant inflammatory factors (such as IL-4 and IL-8) and changing the equilibrium between Treg and Th17 cells.
|
30713661 |
2019 |