|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL4-590*CT/TT and IL4-RP2*253183/183183 were found to predict the risk (2-fold) and severity (3 to 4-fold) of asthma and were associated with a lower FEV1 index.
|
25299150 |
2014 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings provide support for the view that both chromosomes 5 and 11 may contain genes relevant to asthma and atopy, a possible candidate being the interleukin-4 (IL-4) gene cluster.
|
8616554 |
1996 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These results indicate a possible involvement of SNPs in the IL4 gene in the development of asthma and the regulation of total serum IgE.
|
14610476 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Significant differences in the frequency of IL-4 -590T allele and of IL-4Ralpha +1902A allele were also detected in asthmatics in comparison with controls (pless than 0.001 and p=0.005, respectively).
|
23527710 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic and genotype frequencies in IL4 C-33T polymorphism in the asthma group and the control group were not significantly different.
|
20517665 |
2010 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Protective cytokine polymorphisms for BA for seven cytokine genotypes (IL-4 -1098/G:T, TNF- alpha -238/G:G, IL-2 -330/G:T, IL-4 -590/C:T, IFNgamma utr5644/A:T, IL-1beta +3962/C:T, IL-10 -1082/A:G), six cytokine diplotypes, four cytokine haplotypes, and four cytokine alleles were found.
|
18780949 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy.
|
11005866 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease.
|
19254294 |
2009 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
These results provide further evidence for a role of TNF-alpha-308 G/A and IL-4-589 C/T polymorphisms in susceptibility to and severity of asthma.
|
18088017 |
2007 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several independent studies have shown evidence for linkage between the markers flanking IL-4 gene cluster and asthma and/or asthma-related traits.
|
11069564 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs in IL4 were associated with asthma in both races (p-values <0.05).
|
21387019 |
2011 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Our meta-analysis summarized the evidence regarding the association between C-589T polymorphisms in the promoter region of IL-4 gene and asthma.
|
18396027 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the interleukin-4 (C-590T), interleukin-4 receptor (ile50val and gln576arg), and interleukin-13 (arg130gln) genes have been described as susceptibility alleles for asthma.
|
17284225 |
2007 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results do not show an association between [C590T] promoter polymorphism of the IL-4 gene and asthma in Kuwaiti Arabs.
|
10899762 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms in the IL-4 receptor alpha (IL4RA) gene have been associated with asthma and atopy, but with variable success in different populations.
|
17083349 |
2006 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the IL-4 C-589T and C+33T polymorphisms may be risk factors for asthma.
|
23398789 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
While there was only modest evidence for association with single SNPs in the Hutterite and European American samples (P < 0.05), there were highly significant associations in European Americans between asthma and haplotypes comprised of SNPs in the IL4 gene (P < 0.001), including a SNP in a conserved non-coding element.
|
16336695 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that polymorphisms in the IL-4 and IL-4Ralpha chain genes might play a role both conferring susceptibility to and modulating severity of atopy and asthma.
|
12911786 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association between atopy/asthma and the ILe50Val polymorphism of IL-4 receptor.
|
10390422 |
1999 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A total of 214 atopic patients (108 with asthma and 106 with allergic rhinitis) and 120 healthy controls from Pakistan were genotyped for IL-4 SNPs C-589T (rs2243250), T+2979G (rs2227284), and C-33T (rs2070874) using restriction fragment length polymorphism-polymerase chain reaction.
|
23654077 |
2013 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, the IL4*-589T allele was significantly increased in the subjects with fatal or near-fatal asthma compared with nonasthmatic subjects (odds ratio [OR], 1.8; P =.02) and subjects with mild-to-moderate asthma (OR, 1.9; P =.02).
|
10887316 |
2000 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction was found between R130Q in the IL-13 gene (IL13) and I50V in the IL-4 receptor alpha gene (IL4RA) on the risk of asthma, with a cross-validation consistency of 10 of 10 and a prediction error of 33.7% (P = .014).
|
16387595 |
2006 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
When patients were stratified into two groups according to the degree of the severity of asthma, the IL-4 A1 allele was specifically not associated with mild asthma, but highly associated with the moderate and severe forms of the disease.
|
10529588 |
1999 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, IL4 genetics had an effect on susceptibility to H. pylori: asthmatics carrying the IL4 -590 allele T had a diminished risk to be H. pylori infected (OR 0.485 95%CI 0.287-0.819).This effect was not seen in controls.
|
15970635 |
2005 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
|
19770271 |
2009 |