|
Dermatitis, Atopic
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Adult T-Cell Lymphoma/Leukemia
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
These results indicate the activation of IL-4/IL-4 receptor system in leukemic cells from some ATL patients and suggest the possible involvement of the system in the proliferation of leukemic cells and the leukemogenesis in ATL.
|
3262383 |
1988 |
|
Leukemia, T-Cell
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These results indicate the activation of IL-4/IL-4 receptor system in leukemic cells from some ATL patients and suggest the possible involvement of the system in the proliferation of leukemic cells and the leukemogenesis in ATL.
|
3262383 |
1988 |
|
Leukemogenesis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results indicate the activation of IL-4/IL-4 receptor system in leukemic cells from some ATL patients and suggest the possible involvement of the system in the proliferation of leukemic cells and the leukemogenesis in ATL.
|
3262383 |
1988 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Deregulation of the expression of these interleukins was shown to be responsible for various diseases, such as i) IL-4 vs. immediate type hypersensitivity and ii) IL-6 vs. autoimmunity and multiple myelomas.
|
8691054 |
1989 |
|
Multiple Myeloma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Deregulation of the expression of these interleukins was shown to be responsible for various diseases, such as i) IL-4 vs. immediate type hypersensitivity and ii) IL-6 vs. autoimmunity and multiple myelomas.
|
8691054 |
1989 |
|
Refractory anemias
|
0.030 |
Biomarker
|
disease |
BEFREE |
By in situ hybridization, the IL-4 and IL-5 genes were found to be deleted in the 5q- chromosome of four patients with refractory anemia (RA) or therapy-related acute nonlymphocytic leukemia (t-ANLL), who had a del(5q).
|
2783863 |
1989 |
|
Hypercalcemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-3, IL-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF) at the mRNA level in fresh leukemic cells from 20 adult T cell leukemia patients to see whether there is any association between cytokine expression and HTLV-I expression and between their expression and clinical manifestations such as hypercalcemia or neutrophilia.
|
2503474 |
1989 |
|
X-linked agammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
One secreted large amounts of IgM and two secreted small amounts, but none of the XLA lines secreted IgG constitutively or in response to any of the factors (IL-4, BCDF).
|
2539277 |
1989 |
|
Neutrophilia (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-3, IL-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF) at the mRNA level in fresh leukemic cells from 20 adult T cell leukemia patients to see whether there is any association between cytokine expression and HTLV-I expression and between their expression and clinical manifestations such as hypercalcemia or neutrophilia.
|
2503474 |
1989 |
|
Wiskott-Aldrich Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Several of the normal and WAS EBV-transformed LCL also secreted IgM and IgG in response to IL-4.
|
2539277 |
1989 |
|
T-Cell Lymphoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, IL-4 may play an important role in the development of hypergammaglobulinemia as well as in the growth and histopathogenesis of T-cell lymphoma, and gamma-interferon may be responsible for the development of Lennert's lesion.
|
2123745 |
1990 |
|
Hypergammaglobulinemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, IL-4 may play an important role in the development of hypergammaglobulinemia as well as in the growth and histopathogenesis of T-cell lymphoma, and gamma-interferon may be responsible for the development of Lennert's lesion.
|
2123745 |
1990 |
|
Blepharitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of IL-4 results in a marked increase in serum IgE levels and the appearance of an inflammatory ocular lesion (blepharitis) with characteristic histopathologic features seen in allergic reactions.
|
2116236 |
1990 |
|
Malignant histiocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lymph node specimens diagnosed as angioimmunoblastic T-cell lymphoma and angiocentric lymphoma having distinctive histopathological features expressed IL-4 more frequently than other T-cell lymphomas, and all 7 patients expressing IL-4 had hypergammaglobulinemia.
|
2123745 |
1990 |
|
Angioimmunoblastic Lymphadenopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lymph node specimens diagnosed as angioimmunoblastic T-cell lymphoma and angiocentric lymphoma having distinctive histopathological features expressed IL-4 more frequently than other T-cell lymphomas, and all 7 patients expressing IL-4 had hypergammaglobulinemia.
|
2123745 |
1990 |
|
Peripheral T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin 4 and gamma-interferon may play a role in the histopathogenesis of peripheral T-cell lymphoma.
|
2123745 |
1990 |
|
IgG Deficiency disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Selective IgG deficiency with a transcriptional disorder of the gamma switching region gene and the IL-4 gene.
|
2278996 |
1990 |
|
Nasal Type Extranodal NK/T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lymph node specimens diagnosed as angioimmunoblastic T-cell lymphoma and angiocentric lymphoma having distinctive histopathological features expressed IL-4 more frequently than other T-cell lymphomas, and all 7 patients expressing IL-4 had hypergammaglobulinemia.
|
2123745 |
1990 |
|
Alveolitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To investigate the mechanisms accounting for the T cell alveolitis taking place in the lung of HP patients and their pattern of growth, cells recovered from the bronchoalveolar lavage (BAL) of seven patients were evaluated for: 1) the expression of activation markers, including IL-2R (p55 and p75 subunits), HLA-DR and VLA-1 Ag; 2) the ability of IL-2 and IL-4 to induce in vitro proliferation; 3) the capability to synthesize and release IL-2 by determining the levels of IL-2 in BAL cell-free supernatants and by evaluating the presence of mRNA transcripts for IL-2; and 4) the molecular configuration of the beta- and gamma-genes of the TCR.
|
2144545 |
1990 |
|
Inflammatory disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice.
|
2116236 |
1990 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that B-CLLs presented some features in common with the CD23+ umbilical cord blood B cells in as much as, like in B-CLLs; (i) all CD23+ cord blood cells co-expressed CD5 Ag, (ii) freshly isolated CBMC expressed both type A and type B CD23 mRNA, and finally (iii) these cells weakly re-expressed CD23 Ag upon IL-4 stimulation as compared to adult PBMC.
|
1830631 |
1991 |
|
Hodgkin Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Other cytokine expression was rare except two cases of HD with high amounts of IL-4 mRNA.
|
1951632 |
1991 |
|
Myeloid Leukemia, Chronic
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results suggest that basophil progenitors expressing CD4, CD7 and HLA-DR may be involved in the development of basophilic crisis of CML and that both IL-1 and GM-CSF may act on basophil progenitors as well as IL-3 or IL-4.
|
2043482 |
1991 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Significant levels of TNF (578 +/- 917 pg/ml versus 24 +/- 29 pg/ml) (p = 0.01), GM-CSF (24 +/- 41 pg/ml versus less than 8 pg/ml) (p = 0.02), and IL-6 (225 +/- 327 pg/ml versus 7 +/- 12 pg/ml) (p = 0.01), but not IL-1 alpha or IL-4, were detected in the bronchoalveolar lavage fluid (BALF) of patients with symptomatic compared with BALF of patients with asymptomatic asthma.
|
1374772 |
1992 |