|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presepsin, procalcitonin, IL-8, and IL-6 showed a high diagnostic ability for sepsis at admission with area under the curve of 0.934, 0.798, 0.775, and 0.751, respectively.
|
31651475 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is excellent evidence that elevated plasma levels of several biomarkers of endothelial injury, including von Willebrand factor antigen (VWF), angiopoietin-2 (Ang-2), and soluble fms-like tyrosine kinase 1 (sFLT-1), and biomarkers of inflammation, especially interleukin-8 (IL-8) and soluble tumor necrosis factor receptor (sTNFr), identify sepsis patients with a higher mortality.
|
29575977 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We measured plasma (n = 182) and urine (n = 118) activin A (a rapidly released cytosolic neutrophil protein), interleukin-8 (a chemotactic factor for neutrophils), myeloperoxidase (a neutrophil biomarker released in tissues), and interleukin-6 on intensive care unit admission (plasma and urine) and 24 hours later (plasma) in sepsis patients manifesting their first organ dysfunction between 24 hours preceding admission and the second calendar day in intensive care unit.
|
31325317 |
2019 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-8 - 251 A/T polymorphism was also related to the severity and 28-day mortality of sepsis.
|
31598794 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
|
31818332 |
2019 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of IL-8 varied significantly across primary diagnoses with the highest levels occurring in patients with sepsis and the lowest levels in those with asthma.
|
30995942 |
2019 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicated that the levels of TNF-α, IL-6, IL-8, PCT, ET-1 and IL-10 were associated with the condition and prognosis of elderly patients with sepsis, and the assessment system for immune levels based on the levels of these indicators was conducive to the stipulation of individualized immune regulation procedure and prognostic evaluation of sepsis.
|
30112039 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.
|
30228372 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The redox cascade during sepsis is mainly initiated by IL-6 and IL-8 stimulation in newborns and includes multiple noxious processes, as direct cell damage induced by reactive oxygen species, activation of gene expression leading to amplification of inflammation and oxidative stress, and impairment of mitochondrial function.
|
30174784 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess sepsis inflammation, conventional biomarkers (PCT and IL-8) are also monitored.
|
28496179 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
|
28662100 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Septicaemic melioidosis cases showed significant down regulation of IL8 compared to sepsis cases caused by other pathogens.
|
28628607 |
2017 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between rs4073, rs2227306 and rs1126647 polymorphisms and serum levels of IL-8 in patients with sepsis.
|
27642120 |
2016 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated levels of interleukin 8 (IL-8), IL-6, IL-10, monocyte chemotactic protein 1, and CRP were associated with reduced time to posttraumatic sepsis in Cox regression analysis.
|
26496101 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-producing alleles of proinflammatory cytokines protected patients against sepsis (IL1B -511A and IL8 -251A) and mortality (IL1B -511A).
|
25619315 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We, therefore, investigated this polymorphism with serum levels of cytokines TNF-α, IL-6, and IL-8 in relation to development of sepsis following major gastrointestinal surgery.
|
24944154 |
2014 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In response to pathogen infection, pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, IL-18 and tumor necrosis factor-α (TNF-α)] and anti-inflammatory cytokine (IL-10) increased in patients with sepsis.
|
24292568 |
2014 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies focused on discovery of sepsis-related biomarkers have identified interleukin-8 as a robust outcome biomarker in pediatric septic shock.
|
22511139 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we employed in vitro and in vivo models of sepsis to investigate the functional relationship between overtly produced C5a and IL-8.
|
20591742 |
2010 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
|
20217044 |
2010 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of interleukin-8 (IL-8), a known neutrophil chemoattractant, on lipopolysaccharide (LPS) -induced reactive oxygen species (ROS) production by endothelial cells, and its significance in the pathogenesis of LPS-mediated sepsis.
|
20518825 |
2010 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of responders and nonresponders revealed rapid downmodulation of innate IL-1beta and IL-8 sepsis cascade cytokines in both groups, but only responders downregulated IL-17 pathway genes to baseline levels.
|
19895991 |
2009 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between elevated levels of nitric oxide (NO) and IL-8 in acute lung injury associated with sepsis, acute respiratory distress syndrome, respiratory syncytial virus infection in infants, and other inflammatory diseases suggested that NO may play important roles in the control of IL-8 gene expression in the lung.
|
15169673 |
2004 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, serum IL-8 levels were markedly elevated in the SGD individual compared with those of non-SGD individuals in sepsis.
|
14576362 |
2004 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presence of the IL-8 transgene did not improve survival or morbidity nor did it alter peritoneal neutrophil recruitment induced by the cecal ligation and puncture model of sepsis.
|
11549608 |
2001 |