|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma.
|
11781348 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th9 cells preferentially produce IL-9 and participate in allergic responses and asthma.
|
31776325 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approximately half of the Der f-specific Th clones derived from atopic asthmatics produced IL-9 upon TCR stimulation.
|
17541281 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows for the first time that IL-9 is involved in EO homeostasis in CRSwNP and could explain the low benefit of anti-IL-5 therapy for some patients with asthma and nasal polyposis.
|
25704963 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 has been shown to act on many cell types involved in asthma, including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells, and thus might be important in the pathophysiology of allergic asthma.
|
11295641 |
2001 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
|
11842292 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9-producing Th9 cell is a novel Th cell subset involved in type II allergic inflammations such as asthma.
|
28477193 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to assess the contribution of 11-9 to the pathogenesis of BHR in NP by comparing the expression of IL-9 and its receptor in bronchial biopsy specimens from three groups of patients with NP: NP without BHR, NP with asymptomatic BHR, and NP with BHR and asthma.
|
15007348 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was slight increased interaction effect on asthma between transmission of allele 122 of IL-9 gene to offspring and who were exposed to the fur of pets (OR = 3.33, P = 0.047).
|
16611254 |
2006 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we examined the effect of IL-9 overexpression on the subepithelial fibrotic response, a feature of asthmatic remodeling, induced by chronic exposure to Alternaria alternata extract.
|
17446528 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD4(+) T-helper type 2 (T(H)2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9 and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases.
|
21841801 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the effects of IL-9, IL-13 and an IL-9/IL-13 combination, during differentiation of bronchial epithelial cells from normal (n = 6) and asthmatic (n = 8) children.
|
23671562 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This assumption was initially confirmed by functional analyses showing that both IL-9 and Th2 cells play an important role in the pathogenesis of asthma, IgE class switch recombination, and resolution of parasitic infections.
|
22235761 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Th2 cytokine interleukin-9 (IL-9) is one candidate gene for asthma on the basis of position cloning and animal models of airway inflammation.
|
10871433 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T helper 2 (T<sub>H</sub>2)-associated immuno-pathological conditions such as asthma and parasitic infections.
|
31035677 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that the levels of Th9 cells and their cytokine IL-9 in the peripheral blood of mice with bronchial asthma are significantly increased, suggesting that Th9 cells play important roles in the pathogenesis of asthma.
|
29456652 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 9, a type 2 cytokine has been proposed as a key cytokine in susceptibility to asthma.
|
15051283 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These findings demonstrate that IL-9 is specifically upregulated after local allergen challenge in the lungs of atopic asthmatic patients.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-9 was measured in 10 atopic subjects with mild asthma and 5 nonatopic healthy control subjects at baseline and 24 hours after segmental sham and allergen challenge.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, both experimental and genetic studies point to TH2 cytokines, such as IL-4, IL-13, IL-5, and IL-9, as important targets for therapeutic applications in patients with asthma.
|
11477111 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to ascertain whether it is a successful translation from bench to bedside, the biological features of IL-9 were evaluated and up-to-date information regarding the role of IL-9 in different experimental murine models and human asthma were summarized.
|
28352305 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL12B gene encodes the p40 chain of IL-12, a proinflammatory cytokine that antagonizes TH2 expression and hence may play a critical role in the pathogenesis of airway inflammation observed in asthma.
|
15007350 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma.
|
9328470 |
1997 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 targets cells of the lymphoid, myeloid and mast cell lineages, and is likely to contribute to the development of allergic and autoimmune diseases such as asthma, arthritis, multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
|
23291628 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses.
|
18349591 |
2008 |