|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma.
|
9328470 |
1997 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results provide supportive evidence for linkage between asthma and gene markers in or near the interleukin-4 (IL-4) gene, the IL-9 gene, and D5S393 on chromosome 5q31-q33 (p = 0.0013, p = 0.018, and p = 0.0077, respectively).
|
9372650 |
1997 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
|
10224407 |
1999 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies use recombinant inbred mice to demonstrate that BHR in mouse models of asthma is associated with a genetic alteration at the IL-9 locus, where IL-9 expression in lung is strongly associated with bronchial responsiveness.
|
10329852 |
1999 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data are supported by the finding that allergen-exposed IL-9-transgenic mice exhibit many features that are characteristic of human asthma (airway eosinophilia, elevated serum IgE and bronchial hyperresponsiveness) as compared to the background strain.
|
10427975 |
1999 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the contribution of IL-9 to the pathogenesis of asthma, we examined the expression of IL-9 and its receptor (IL-9R) in bronchial tissue from subjects with atopic asthma (n = 10), chronic bronchitis (n = 11), and sarcoidosis (n = 9) and from atopic (n = 7) and nonatopic (n = 10) healthy control subjects.
|
10629460 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 is a Th2 cytokine active on various cell types such as T and B lymphocytes, mast cells, and eosinophils, and potentially involved in allergy and asthma.
|
10657629 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, these results suggest that upregulation of mucin by IL-9 might contribute to the pathogenesis of human inflammatory airway disorders, such as asthma.
|
10837360 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Th2 cytokine interleukin-9 (IL-9) is one candidate gene for asthma on the basis of position cloning and animal models of airway inflammation.
|
10871433 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, linkage data in human and mice have suggested that IL9 may contribute to asthma.
|
11039580 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 has been shown to act on many cell types involved in asthma, including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells, and thus might be important in the pathophysiology of allergic asthma.
|
11295641 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, both experimental and genetic studies point to TH2 cytokines, such as IL-4, IL-13, IL-5, and IL-9, as important targets for therapeutic applications in patients with asthma.
|
11477111 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma.
|
11686869 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, expression of mCLCA3 was induced in the lung of antigen-exposed mice, and this induction could be suppressed by neutralizing IL-9 antibody treatment, indicating IL-9 is both necessary and sufficient to induce mCLCA3 in this experimental model of asthma.
|
11694454 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma.
|
11781348 |
2002 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of sib pair linkage studies of asthma and the interleukin-9 gene (IL9).
|
11793651 |
2001 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
|
11842292 |
2002 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We demonstrate significant increases in IL-9 (P <.001) and IL-9R (P <.05) immunoreactivity, as well as increased expression of HCLCA1 mRNA (P <.001), in the epithelium of asthmatic patients compared with that found in control subjects.
|
11842292 |
2002 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The numbers of IL-9 mRNA(+) cells present in the bronchial mucosa were significantly greater in atopic asthmatics than those in normal controls (P = 0.003).
|
12047433 |
2002 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These findings demonstrate that IL-9 is specifically upregulated after local allergen challenge in the lungs of atopic asthmatic patients.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-9 was measured in 10 atopic subjects with mild asthma and 5 nonatopic healthy control subjects at baseline and 24 hours after segmental sham and allergen challenge.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to assess the contribution of 11-9 to the pathogenesis of BHR in NP by comparing the expression of IL-9 and its receptor in bronchial biopsy specimens from three groups of patients with NP: NP without BHR, NP with asymptomatic BHR, and NP with BHR and asthma.
|
15007348 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL12B gene encodes the p40 chain of IL-12, a proinflammatory cytokine that antagonizes TH2 expression and hence may play a critical role in the pathogenesis of airway inflammation observed in asthma.
|
15007350 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 9, a type 2 cytokine has been proposed as a key cytokine in susceptibility to asthma.
|
15051283 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was slight increased interaction effect on asthma between transmission of allele 122 of IL-9 gene to offspring and who were exposed to the fur of pets (OR = 3.33, P = 0.047).
|
16611254 |
2006 |