|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was slight increased interaction effect on asthma between transmission of allele 122 of IL-9 gene to offspring and who were exposed to the fur of pets (OR = 3.33, P = 0.047).
|
16611254 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma.
|
9328470 |
1997 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genes encoding IL-9 and IL-9R have recently been implicated in the genetic basis of asthma and allergy.
|
21371865 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies use recombinant inbred mice to demonstrate that BHR in mouse models of asthma is associated with a genetic alteration at the IL-9 locus, where IL-9 expression in lung is strongly associated with bronchial responsiveness.
|
10329852 |
1999 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with the dominant genotype for these IL9 polymorphisms were more likely to report a severe asthma exacerbation if exposed to increased dust mite levels.
|
25913104 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of sib pair linkage studies of asthma and the interleukin-9 gene (IL9).
|
11793651 |
2001 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results provide supportive evidence for linkage between asthma and gene markers in or near the interleukin-4 (IL-4) gene, the IL-9 gene, and D5S393 on chromosome 5q31-q33 (p = 0.0013, p = 0.018, and p = 0.0077, respectively).
|
9372650 |
1997 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.
|
10224407 |
1999 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, genome-wide association studies have revealed that variants of the gene encoding the IL-23 receptor, as well as the locus harboring the gene encoding the p40 chain, confer genetic risk for developing Crohn's disease (CD) and ulcerative colitis (UC).
|
24138637 |
2013 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn's disease (CD).
|
29909019 |
2018 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether a TaqI polymorphism in the 3'UTR of the IL-12 p40 gene affects secretion of IL-12 in vitro, and whether this polymorphism is associated with susceptibility to Crohn's disease (CD).
|
12424624 |
2002 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ustekinumab, an inhibitor of the p40 subunit of interleukins 12 and 23, is an effective treatment for patients with Crohn's disease (CD).
|
28365485 |
2017 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms within the genes encoding the IL-12 p40 subunit, IL12B, and one of the IL-23 receptor subunits, IL23R, have been replicated in US and European populations and overlap with risk of Crohn's disease.
|
18830267 |
2009 |
|
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent genomic studies have identified genetic variants in the IL12B gene, which encodes the p40 subunit shared by interleukin 12 and interleukin 23, as susceptibility loci for inflammatory bowel disease (IBD).
|
23573954 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of Ewing sarcoma despite overt epithelial differentiation including diffuse expression of cytokeratins and p40.
|
30285997 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These include several genes that are good candidates for a tumor-suppressor gene, as well as the genes encoding five hematopoietic growth factors (CSF2, IL3, IL4, IL5, and IL9).
|
8516290 |
1993 |
|
Psoriasis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 and Th17 biology, respectively, and genetic variation in this region significantly influences risk of psoriasis.
|
23376980 |
2013 |
|
Multiple Sclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis.
|
15988104 |
2005 |
|
Bronchial Hyperreactivity
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
At the interleukin-9 (IL-9) locus, the 118 allele showed significant association with serum total IgE (p<0.003) but not with histamine BHR.
|
8616554 |
1996 |
|
X-Linked Combined Immunodeficiency Diseases
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Our laboratory has identified an X-linked severe combined immunodeficiency (XSCID) in dogs that is the result of mutations in the common gamma chain (gammac) subunit of the interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 receptors.
|
12857971 |
2003 |
|
X-Linked Combined Immunodeficiency Diseases
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Our laboratory has identified and characterized an X-linked severe combined immunodeficiency (XSCID) in dogs that is due to mutations in the common gamma (gamma c) subunit of the interleukin-2 (IL2), IL4, IL7, IL9, and IL15 receptors.
|
9479568 |
1998 |
|
X-Linked Combined Immunodeficiency Diseases
|
0.060 |
GeneticVariation
|
group |
BEFREE |
X-linked severe combined immunodeficiency (XSCID) constitutes a disorder of the immune system caused by mutations in the gene encoding the common gamma chain (gammac), a subunit of the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors, which are necessary for lymphocyte development and function.
|
9921912 |
1998 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
No significant associations of TNF-alpha and IL-9 polymorphisms with RSV bronchiolitis were observed.
|
14722888 |
2004 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the IL-9 genetic polymorphism (rs2069885) has an opposite effect on the risk of severe RSV bronchiolitis in boys and girls.
|
20503287 |
2010 |
|
Alzheimer's Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In the gene-gene interaction analysis, we found that IL-9/IL-9R genotype rs31563 GG/rs3093467 TT conveyed a greater risk for AD phenotype development.
|
21371865 |
2011 |