|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS.
|
19939284 |
2009 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions.
|
21138342 |
2011 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Stimulation with S. epidermidis sepsis strains induced higher IL-6 and IL-10 expression than stimulation with colonization strains.
|
30146415 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10.
|
31370884 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis.
|
29506272 |
2018 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis.
|
30538802 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.
|
28052995 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Following CASP, Dusp1(-/-) mice had increased serum levels of CCL4, interleukin-10 (IL-10) and IL-6, with differences from wild-type mice being dependent on severity of sepsis.
|
20561086 |
2010 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL6 had the most sensitivity and IL10 had the most specificity for diagnosis of sepsis.
|
29239828 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously shown that intrathymic delivery of IL-10 with an adenoviral vector in wild-type mice significantly improves outcome to sepsis.
|
18959626 |
2008 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis.
|
28769538 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We therefore conclude that high production of IL-10 by monocytes may, in part, explain the greater propensity for <i>S</i> Choleraesuis to induce human sepsis and that this may be greater in strains such as A50, which induces both high IL-10 production and monocyte survival.
|
30037797 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This work attempts to further quantitatively assess the association of three widely evaluated polymorphisms of IL-10 (-592C/A, -819C/T, -1082A/G) with sepsis susceptibility through a meta-analysis.
|
25497741 |
2015 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively.
|
27592234 |
2016 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These and other research data clearly demonstrated that the -1082 A/G polymorphism in the IL-10 gene promoter has an important impact on susceptibility of sepsis and sepsis outcome.
|
20236506 |
2010 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other candidate genes for sepsis and septic shock include the interleukin (IL)-1 receptor antagonist gene, the heat shock protein gene, the IL-6 gene, the IL-10 gene, the CD-14 gene, the Toll-like receptor (TLR)-4 gene, and the TLR-2 gene, to name a few.
|
12970043 |
2003 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that IL-10 reduction of T-cell functionality was associated with increased FOXP3 expression in CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>-</sup> regulatory T cells as observed in sepsis.
|
29182416 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients with IL-10 (-1082A/A) genotypes were found significantly higher in post traumatic sepsis patients and had a significantly higher risk to developed sepsis complication (p < 0.05, OR = 0.86, C.I = 0.08-8.8).In case of TNF-α (-308) position, GA and GG genotype patients have a significantly lower risk of poor outcome (p < 0.05, OR = 0.25, C.I = 0.01-1.3) and (p < 0.05, OR = 0.22, C.I = 0.01-0.5) in comparison to AA genotype.
|
26561011 |
2015 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In response to pathogen infection, pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, IL-18 and tumor necrosis factor-α (TNF-α)] and anti-inflammatory cytokine (IL-10) increased in patients with sepsis.
|
24292568 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available.
|
30547887 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This suggests that interleukins such as IL-6 and IL-10 have a close association with coagulopathy and fibrinolytic dysregulation in sepsis and can be considered as candidates for potential therapeutic targets in SAC.
|
27449508 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We subjected IL-10-deficient (IL-10(-/-)) and wild-type (IL-10(+/+)) mice to CLP and monitored the progression of sepsis, the onset of irreversible shock, and mortality.
|
12117955 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032).
|
12411588 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We detected higher serum levels of cytokines TNF-α (5.7 vs. 0.7 pg/ml, P < 0.001), IL-6 (24.8 vs. 3.8 pg/ml, P < 0.001), IL-10 (30.0 vs. 11.9 pg/ml, P = 0.040), and VEGF (177.9 vs. 48.1 pg/ml, P = 0.018) in sepsis sera.
|
28086962 |
2017 |