|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin 8 production in whole blood assays: Is interleukin 10 responsible for the downregulation observed in sepsis?
|
10623443 |
2000 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken.
|
11197608 |
2000 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
|
Septicemia
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Adenoviral delivery of human and viral IL-10 in murine sepsis.
|
11441115 |
2001 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We report here that inhibition of thymocyte apoptosis by targeted adenovirus-induced thymic expression of human IL-10 reduced blood bacteremia and prevented mortality in sepsis.
|
11553765 |
2001 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We subjected IL-10-deficient (IL-10(-/-)) and wild-type (IL-10(+/+)) mice to CLP and monitored the progression of sepsis, the onset of irreversible shock, and mortality.
|
12117955 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032).
|
12411588 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-10 may represent a future target for immunomodulating patients with the sepsis syndrome or critically ill patients at risk of developing infections.
|
12406851 |
2002 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
|
11907099 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other candidate genes for sepsis and septic shock include the interleukin (IL)-1 receptor antagonist gene, the heat shock protein gene, the IL-6 gene, the IL-10 gene, the CD-14 gene, the Toll-like receptor (TLR)-4 gene, and the TLR-2 gene, to name a few.
|
12970043 |
2003 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-10 (IL-10) is an anti-inflammatory cytokine and levels have been shown to be highest in those patients who develop sepsis after trauma or surgery.
|
12925485 |
2003 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, in the patients who developed sepsis, interleukin-10 release at admission to the intensive care unit was significantly lower than in patients who did not subsequently develop sepsis (median [range] 1.47 [0.13-6.90] ng/mL compared with 4.93 [0.03-16.80] ng/mL, p = .001).
|
12544990 |
2003 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms within the IL-10 gene may be predictors of outcome in patients with sepsis from pneumonia.
|
16162776 |
2005 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results demonstrate the advantageous role of de novo IL-10 synthesis in early stages of sepsis and suggest the beneficial impact of gene transfer approach to recombinant protein infusions.
|
16783196 |
2006 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis.
|
16435103 |
2006 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously shown that intrathymic delivery of IL-10 with an adenoviral vector in wild-type mice significantly improves outcome to sepsis.
|
18959626 |
2008 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS.
|
19939284 |
2009 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Following CASP, Dusp1(-/-) mice had increased serum levels of CCL4, interleukin-10 (IL-10) and IL-6, with differences from wild-type mice being dependent on severity of sepsis.
|
20561086 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These and other research data clearly demonstrated that the -1082 A/G polymorphism in the IL-10 gene promoter has an important impact on susceptibility of sepsis and sepsis outcome.
|
20236506 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude allelic variations in PLA2G2A, TLR2, TLR5, and IL10 may moderate the predisposition to sepsis in preterm infants.
|
20463618 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.
|
20835611 |
2010 |