|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.
|
29728642 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2Rα/β independently of FoxP3.
|
26813346 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Treatment of C3H.IL-10(-/-) mice with fenofibrate delayed the onset of colitis, decreased the colonic histopathology score, and decreased colonic expression of genes encoding the inflammatory cytokines interferon-gamma and interleukin (IL)-17.
|
17631136 |
2007 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
SCFAs mix protected from AOM/DSS-induced colorectal cancer by improving colon inflammation and disease activity index score as well as suppressing the expression of proinflammatory cytokines including IL-6, TNF-α and IL-17.
|
29694938 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the effect of IL-17A on colitis in IL-10-deficient (Il10-/-) mice.
|
31755523 |
2020 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.
|
27322655 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis.
|
30297787 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The degree of colitis was associated with general changes in the complexity of the microbiota and was corroborated by quantitative analyses of the Bacteroides and Lactobacillus High gene expression levels of IL-17 and IFN-γ in colon and caecum were detected in Gαi2(-/-) mice with moderate and severe colitis.
|
27162181 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis.
|
28159898 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the absence of IFNγ, intestinal inflammation in CD4 T cell recipient mice was associated with enhanced IL17 responses; consequently, targeting IL17 signaling in IFNγ-deficient mice reduced T cell-mediated colitis.
|
29416538 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Notably, lentivirus-mediated overexpression of Ascl2 remarkably alleviated the severity of 2,4,6-trinitrobenzenesulfonic acid solution (TNBS)-induced colitis in mice, with decreased level of colonic IL-17A.
|
30722992 |
2019 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mice with conditional deletion of HDAC2 in CD4<sup>+</sup> T cells have elevated IL-17 expression and severe colitis.
|
30375383 |
2018 |
|
Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, key cytokines associated with colitis (IL-1β, IL-6, and IL-17A) were significantly suppressed, following treatment with M2b macrophage exosomes.
|
31749791 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4<sup>+</sup> T cells.
|
28582593 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RhoA<sup>ΔCD4</sup> mice had a similar phenotype to Pggt1b<sup>ΔCD4</sup> mice, including development of colitis, increased numbers of CD4+ T cells in colon, increased expression of integrin alpha4beta7 by CD4+ T cells, and increased levels of IL17A and other inflammatory cytokines in lamina propria.
|
31302143 |
2019 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Melatonin stifled the expression of colonic IL-17 in mice with DSS-induced colitis.
|
28929336 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
VPR-254 reduced the production of key pro-inflammatory cytokines (e.g., IL-17) in ex vivo and in vivo models of colitis.
|
31549280 |
2020 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
[Nature 2010;464:1371-1375] recently reported the accumulation of IL-23-responsive innate lymphoid cells in the colon, the former capable of producing IL-17 and interferon γ and mediating innate colitis in mice.
|
22796792 |
2012 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
When transferred in vivo, Th17 cells lacking Ndfip1 were more likely to maintain their ability to make IL-17, were more potent proinflammatory cytokine producers, and were powerful inducers of colitis.
|
28051111 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Altogether, the AA-mTORC1-IL-17 axis has broad therapeutic implications for IL-17-associated diseases, such as EAE, allergies, and colitis.
|
26558536 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggested that CoQ10 may reduce the severity of colitis and suppress inflammation through the inhibition of p-STAT3 and IL-17.
|
28816577 |
2017 |