ING1, inhibitor of growth family member 1, 3621

N. diseases: 99; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 GeneticVariation group BEFREE ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction. 12637159 2003
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma
0.010 GeneticVariation disease BEFREE We analyzed the loss of heterozygosity (LOH) status of the ING family (ING1-ING5) chromosomal loci in a group of ameloblastomas by microsatellite analysis, and correlated the ING LOH status with clinicopathological characteristics. 20681410 2010
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.010 GeneticVariation disease BEFREE Apolipoprotein E (APOE) E4, apolipoprotein B-100 (APOB) Q3611 allele, the angiotensin converting enzyme (ACE) deletion (D) allele and glycoprotein IIIa (GP3A) P33 mutant allele are reported to predispose to early-onset coronary heart disease (CHD). 10463820 1999
CUI: C0027533
Disease: Neck Neoplasms
Neck Neoplasms
0.010 GeneticVariation group BEFREE Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions. 10679922 2000
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.010 GeneticVariation group BEFREE Our study demonstrates that overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. 25613480 2015
CUI: C4290046
Disease: trachomatis
trachomatis
0.010 GeneticVariation disease BEFREE The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. 16959883 2006
Squamous cell carcinoma of the head and neck
0.710 Biomarker disease BEFREE Because ING1 resides on the long arm of chromosome 13 (13q34) (a region frequently deleted in many tumor types), we sought to characterize its role in head and neck squamous-cell carcinoma (HNSCC). 10679922 2000
Squamous cell carcinoma of the head and neck
0.710 Biomarker disease CTD_human
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.320 Biomarker disease CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0011616
Disease: Contact Dermatitis
Contact Dermatitis
0.300 Biomarker disease CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.300 Biomarker group CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0162351
Disease: Contact hypersensitivity
Contact hypersensitivity
0.300 Biomarker phenotype CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0235874
Disease: Disease Exacerbation
Disease Exacerbation
0.300 Biomarker phenotype CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker disease CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease BEFREE Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer. 29729696 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease HPO
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease LHGDN Nuclear to cytoplasmic shift of p33(ING1b) protein from normal oral mucosa to oral squamous cell carcinoma in relation to clinicopathological variables. 17805569 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.160 Biomarker disease BEFREE Mutational analysis of the candidate tumor suppressor gene ING1 in Indian oral squamous cell carcinoma. 11287275 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE This study suggests that neither perturbation of alternative splicing, nor mutation of p33/ING1 plays a significant role in the development of haematological malignancies. 12008079 2002
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear. 18381585 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear. 17918192 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Inhibitor of Growth 1 (ING1) is recognized as candidate tumor suppressor. 18450387 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Recently, a potential tumour suppressor gene ING1 (inhibitor of growth 1) was shown to inhibit cell growth and induce apoptosis in the presence of p53. 11966686 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE These results suggest that p33(ING1) may not be a major candidate tumor suppressor gene in myeloid leukemias. 11835353 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Clinical and experimental evidence suggest that the p33ING1b candidate tumor suppressor functionally cooperates with p53 in controlling biochemical and biological functions. 14676120 2003