|
Triple-Negative Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Triple negative breast cancer subtype was associated with higher expression of IRF1, FOXC1 and MKI67.
|
22489698 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor immune rejection has been previously linked to the activation of the interferon-stimulated genes (ISG) STAT1, IRF-5 and IRF-1.
|
28507795 |
2017 |
|
Malignant Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types.
|
11846974 |
2002 |
|
Primary malignant neoplasm
|
0.070 |
GeneticVariation
|
group |
BEFREE |
IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types.
|
11846974 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.
|
15878912 |
2005 |
|
MYELODYSPLASTIC SYNDROME
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Interferon regulatory factor-1 (IRF-1) mRNA expression was examined in specific cell populations (BMMC, CD34+ and CD71+) derived from 45 MDS patients and 20 controls.
|
16483648 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IRF-1 is a tumor suppressor and the expression profile of RIG-I together with its regulation by IRF-1 and the presence of a caspase-recruitment domain in RIG-I suggest that RIG-I might also possess tumor suppressor properties.
|
17516545 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) is a tumor suppressor and transcriptional modulator that can regulate gene expression involved in cell growth control, induction of apoptosis, and post-translation modification.
|
18472010 |
2008 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis.
|
18497060 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
IRF1 binding sites were also upstream of nearly all genes with both increased H4ac and gene expression. alpha-IFN was a significant contributor to both expression and H4ac patterns, but the greatest concordance was seen in the enrichment of certain transcription factor binding sites upstream of genes with increased H4ac in SLE and genes with increased H4ac after alpha-IFN treatment.
|
19710693 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) is a transcription factor that acts as a tumor suppressor and causes apoptosis in cancer cells.
|
19851330 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation.
|
19962964 |
2010 |
|
Monoblastic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells.
|
21740303 |
2011 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
IRF-1 plays a role in this growth suppression as shown by significant resistance to growth suppression in a breast cancer cell line stably transfected with short hairpin RNA against IRF-1.
|
21817116 |
2011 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
IRF-1 plays a role in this growth suppression as shown by significant resistance to growth suppression in a breast cancer cell line stably transfected with short hairpin RNA against IRF-1.
|
21817116 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor 1 (IRF1) shows tumor-suppressor activity by suppressing proliferation of cancer cells.
|
22890831 |
2012 |
|
HIV disease progression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interferon regulatory factor 1 polymorphisms previously associated with reduced HIV susceptibility have no effect on HIV disease progression.
|
23799084 |
2013 |
|
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 1 is an independent predictor of platinum resistance and survival in high-grade serous ovarian carcinoma.
|
24995581 |
2014 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 1 is an independent predictor of platinum resistance and survival in high-grade serous ovarian carcinoma.
|
24995581 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 1 is an independent predictor of platinum resistance and survival in high-grade serous ovarian carcinoma.
|
24995581 |
2014 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
IRF1 was upregulated in human IBD and in the colon epithelium of mice with dextran sulfate sodium-induced colitis.
|
25208103 |
2014 |
|
Colitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
IRF1 was upregulated in human IBD and in the colon epithelium of mice with dextran sulfate sodium-induced colitis.
|
25208103 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRF-1 binding around transcribed regions was increased in SLE patient monocytes, but histone modifications at potential IRF-1 binding sites without detectable IRF-1 binding were increased as well.
|
25418955 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRF-1 inhibition may serve as a novel target for treatment of SLE-associated inflammation and organ damage.
|
28564495 |
2017 |
|
Edema of foot (finding)
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
IRF-1 expression limited CHIKV-induced foot swelling in joint-associated tissues and prevented dissemination of CHIKV and RRV at early time points.
|
28835505 |
2017 |