IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 AlteredExpression disease BEFREE Alterations in IRF1/IRF2 expression in acute myelogenous leukemia. 11559933 2001
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 AlteredExpression disease BEFREE Thus, accelerated exon skipping results in a loss of IRF-1 expression and function that cannot be overcome by exposure to inducing agents in a subset of AML patients with -5/del(5q) and in APL. 10602416 1999
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease BEFREE Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated. 8634413 1996
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 GeneticVariation disease BEFREE We have investigated the allelic loss of IRF1 in a group of 12 patients with MDS and a 5q deletion and 2 patients with AML and a 5q deletion. 8219215 1993
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease GENOMICS_ENGLAND
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 AlteredExpression disease BEFREE Mechanistically, we found that metformin depressed YAP promoter by competing with the binding of the transcription factor IRF-1 in lung cancer cells. 30389502 2018
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 AlteredExpression disease BEFREE Mechanistically, we found that metformin depressed YAP promoter by competing with the binding of the transcription factor IRF-1 in lung cancer cells. 30389502 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.310 Biomarker disease CTD_human
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 Biomarker disease GENOMICS_ENGLAND
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.300 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.300 Biomarker group CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.300 Biomarker disease CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.300 Biomarker group CTD_human
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation disease CGI
CUI: C0154060
Disease: Carcinoma in situ of stomach
Carcinoma in situ of stomach 		0.300 CausalMutation disease CGI
CUI: C0496905
Disease: Neoplasm of uncertain or unknown behavior of stomach
Neoplasm of uncertain or unknown behavior of stomach 		0.300 CausalMutation disease CGI
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker disease CTD_human
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.210 Biomarker group RGD [Transcription factors in spinal dorsal root ganglion in rats recurrently infected with respiratory syncytial virus]. 20045913 2009
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.210 Biomarker group BEFREE These observations suggest that RSV infection of human respiratory epithelial cells induces the iNOS gene both in vitro and in vivo; this induction may occur rather promptly and involves transcriptional activator IRF-1 induced by the RSV infection itself. 10410996 1999
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C1153706
Disease: Endometrial adenocarcinoma
Endometrial adenocarcinoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C1336905
Disease: Endometrial Endometrioid Adenocarcinoma
Endometrial Endometrioid Adenocarcinoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C0009766
Disease: Allergic Conjunctivitis
Allergic Conjunctivitis 		0.200 Biomarker disease RGD Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats. 14605445 2003
CUI: C0029866
Disease: Other ureteric obstruction
Other ureteric obstruction 		0.200 Biomarker phenotype RGD Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction. 12787392 2003
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.200 Biomarker group RGD Activation of type II alveolar epithelial cells during acute endotoxemia. 11880315 2002