|
Adult Liver Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Accordingly, inhibition of c-jun gene function is thought to be important for the therapy of liver cancer.
|
21225234 |
2011 |
|
Adult Lymphoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that deregulation of AP-1 expression in CTCL is the result of aberrant expression of JUNB and possible JUND resulting from genomic amplification and constitutive activation of ERK1/2 MAPK in this type of lymphoma.
|
18494816 |
2008 |
|
Adult Lymphoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we show that the activator protein 1 family members JUN and JUNB promote lymphoma development and tumor dissemination through transcriptional regulation of platelet-derived growth factor receptor-β (PDGFRB) in a mouse model of NPM-ALK-triggered lymphomagenesis.
|
23064464 |
2012 |
|
Adult Lymphoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, using a combination of RNA interference and gene expression profiling, we identified Jun target genes that are associated with disseminated lymphoma.
|
25533033 |
2015 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
These anti-ATLL effects were associated with the suppression of SYK and JAK/STAT signaling, along with that of the downstream factors, AKT, ERK, activator protein‑1 and nuclear factor-κB.
|
30066853 |
2018 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Previously, we investigated the transcriptional control of CCR4 expression in ATLL and have found that an activating protein 1 (AP1) family member, FBJ murine osteosarcoma viral oncogene homolog (FOS)-related antigen 2 (FRA2), is consistently expressed at high levels in ATLL and, together with v-JUN avian sarcoma virus 17 oncogene homolog D (JUND), up-regulates the expression of CCR4 as well as that of several proto-oncogenes such as v-MYB myeloblastosis viral oncogene homolog (MYB), murine double minute 2 homolog (MDM2), and B-cell lymphoma 6 (BCL6).
|
22493372 |
2012 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Deregulated expression of AP-1 transcription factors is implicated in the pathogenesis of various lymphomas such as classical Hodgkin lymphomas, anaplastic large cell lymphomas, diffuse large B cell lymphomas and adult T cell leukemia/lymphoma.
|
27600282 |
2017 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study examined the status of the oncogenic transcription factor AP-1 in leukemic cells freshly isolated from patients with ATL.
|
10845928 |
2000 |
|
Agenesis of corpus callosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blot analysis of MAPK, AKT, activator protein-1, and nuclear factor-κB signaling revealed that the ACC cell lines are unresponsive to lipopolysaccharide action.
|
20826579 |
2010 |
|
Alzheimer Disease, Early Onset
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.
|
15917097 |
2005 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases.
|
15917097 |
2005 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10).
|
23546882 |
2013 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Integration of transcriptome data with protein-protein and transcriptional regulatory interactions resulted with central (hub) proteins (UBA52, RAC1, CREBBP, AR, RPS11, SMAD3, RPS6, RPL12, RPL15, and UBC), regulatory transcription factors (FOXC1, GATA2, YY1, FOXL1, NFIC, E2F1, USF2, SRF, PPARG, and JUN) and microRNAs (mir-335-5p, mir-26b-5p, mir-93-5p, mir-124-3p, mir-17-5p, mir-16-5p, mir-20a-5p, mir-92a-3p, mir-106b-5p, and mir-192-5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD.
|
30606694 |
2019 |
|
Amyloidosis cutis dyschromia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whether the use of PTK and AP-1 inhibitors has therapeutic ramifications in the management of ACD remains to be investigated.
|
17518770 |
2007 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Of particular interest, amplicons containing genes involved in the c-jun NH2-terminal kinase/mitogen-activated protein kinase pathway, that is, JUN in 1p32 and MAP3K7IP2 (TAB2) in 6q24-25, were found to be independently amplified in eight of 11 cases with 12q amplification, providing strong support for the notion that aberrant expression of this pathway is an important step in the dedifferentiation of liposarcomas.
|
16732325 |
2006 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the findings suggest that GMSC-derived EVs promoted the expression of Schwann cell dedifferentiation/repair phenotype-related genes <i>in vitro</i>, particularly c-JUN, a key transcription factor that drives the activation of repair phenotype of Schwann cells during PNI and regeneration.
|
30311853 |
2019 |
|
androgen independent prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate for the first time that a combined aberrant activation of NF-kappaB p50 and p65 and AP-1 JunD and Fra-1 in androgen-independent prostate cancer cells results in deregulated IL-6 expression, suggesting a novel potential entry point for therapeutic intervention in prostate cancer.
|
12727841 |
2003 |
|
Anemia of chronic disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Whether the use of PTK and AP-1 inhibitors has therapeutic ramifications in the management of ACD remains to be investigated.
|
17518770 |
2007 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previously, we have reported PlGF (placental growth factor)-mediated transcriptional up-regulation of PAI-1 (SERPINE1) mRNA expression via activation of HIF-1α (hypoxia-inducible factor-1α) and AP-1 (activator protein-1) in HPMVECs (human pulmonary microvascular endothelial cells), which resulted in elevated PAI-1 in humans with SCA (sickle cell anaemia).
|
21175428 |
2011 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDK5, p35, and p39 were rarely expressed in pancreatic ducts whereas more than 90% of PDACs had increased levels of CDK5 and p35.
|
21825040 |
2011 |
|
Anoxia
|
0.020 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia/reoxygenation activated Plk3 in HCE cells to directly phosphorylate c-Jun proteins at phosphorylation sites Ser-63 and Ser-73, and to increase DNA binding activity of c-Jun, detected by EMSA.
|
18650425 |
2008 |
|
Anoxia
|
0.020 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway.
|
16844113 |
2006 |
|
Aortic Aneurysm, Abdominal
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The purpose of the present study was to investigate whether c‑Jun/AP‑1 mediates Chop overexpression in AAA. c‑Jun/AP‑1 and Chop protein levels were determined in an angiotensin II (Ang II)‑induced AAA model using apolipoprotein E‑deficient mice.
|
30864718 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA and protein analysis showed that PAA and AAA are both characterized by a marked activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) proinflammatory transcription factors, and hyperexpression of interleukin (IL)-6 and IL-8.
|
20488324 |
2010 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling plays a pivotal role in growth and survival of prostate cancer cells. c-Jun is an important member of the activator protein 1 (AP-1) family and was shown to interact with AR.
|
23523566 |
2013 |