KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 886; N. variants: 38
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Phase II study of the Multikinase inhibitor of angiogenesis, Linifanib, in patients with metastatic and refractory colorectal cancer expressing mutated KRAS. 28353122 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer. 28749408 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE The Japanese Society of Medical Oncology (JSMO) previously published 2 editions of the clinical guidelines: "Japanese guidelines for testing of KRAS gene mutation in colorectal cancer" in 2008 and "Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients" in 2014. 29873882 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer. 28600477 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Influence of mucinous and necrotic tissue in colorectal cancer samples on KRAS mutation analysis. 28551386 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Circulating tumor DNA is effective for detection of KRAS mutation in colorectal cancer: a meta-analysis. 28885658 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE ME1 was significantly upregulated in KRAS-mutant CRCs. 28475173 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE The KRAS oncogene is involved in the pathogenesis of several types of cancer, particularly colorectal cancer (CRC). 29304017 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). 29374690 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE KRAS mutation is an early event in colorectal cancer carcinogenesis. 28445136 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer. 28422714 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. 28173629 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE MicroRNA‑337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. 29048669 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Mutant KRAS proto‑oncogene GTPase (KRAS) serves an important role in predicting the development, diagnosis, treatment and efficacy of targeted drug therapies for colorectal cancer. 28677778 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Genetic variability in KRAS and EGFR predicts response to cetuximab in irinotecan refractory colorectal cancer. 28025786 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE The aim of the study was to evaluate the current rate of molecular testing prescription (KRAS codons 12/13, BRAF and microsatellite instability (MSI)) in newly diagnosed colorectal cancer (CRC) patients and to determine which factors influence testing. 29137623 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Current guidelines for colorectal cancer (CRC) only recommend genomic assessment of <i>KRAS, NRAS, BRAF,</i> and microsatellite instability (MSI) status.<i>ALK</i> rearrangements are rare in CRC, but patients with activating <i>ALK</i> fusions have responded to targeted therapies<i>ALK</i> rearrangements can be detected by genomic profiling of ctDNA from blood or tissue, and this methodology may be informative in cases where immunohistochemistry (IHC) or other standard testing is negative. 28507204 2018
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Expression of HSP90 and Topo I, and KRAS gene mutations were estimated in primary CRCs. 28870917 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE A large, prospective randomized trial is now ongoing (EVEREST 2) and the results of this trial may contribute to personalized medicine in KRAS wild-type colorectal cancer patients. 26811634 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Here, we report that MAPK signaling shows strong intratumoral heterogeneity and unexpectedly remains regulated in colorectal cancer irrespective of KRAS mutation status. 28202525 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE Prognostic value of KRAS codon 13 gene mutation for overall survival in colorectal cancer: Direct and indirect comparison meta-analysis. 28858102 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 GeneticVariation disease BEFREE We selected one hundred and twenty eight patients diagnosed with advanced colorectal cancer with a KRAS and NRAS unmutated tumor. 26824184 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Neutral evolution of drug resistant colorectal cancer cell populations is independent of their KRAS status. 28981524 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer. 27943267 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.600 Biomarker disease BEFREE Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer. 28459468 2017